Evidence map›Paper›PMID 39791347›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2025

Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper.

M Destoop, P Mohr, F Butlen, P Kéri, J Samochowiec, L De Picker, A Fiorillo, K P C Kuypers, G Dom

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland.The international journal of neuropsychopharmacology · 2026
    Review
  2. Review
  3. European Psychiatry: 2025 in review.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M DestoopCollaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.
P MohrClinical Department, National Institute of Mental Health, Klecany, Czech Republic.ORCID 0000-0002-9851-3271
F ButlenOffice for Neurological and Psychiatric Disorders, European Medicines Agency, Amsterdam, The Netherlands.ORCID 0000-0002-8305-2089
P KériGlobal Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe), Brussels, Belgium.
J SamochowiecPomeranian Medical University in Szczecin, Szczecin, Poland.ORCID 0000-0003-1438-583X
L De PickerCollaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-6883-0559
A FiorilloDepartment of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID 0000-0002-6926-0762
K P C KuypersDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-7634-3809
G DomCollaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-6492-0429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent years show an exponential increased interest ("renaissance") in the use of psychedelics for the treatment of mental disorders and broader. Some of these treatments, such as psilocybin for depression, are in the process of formal regulation by regulatory bodies in the US (FDA) and Europe (EMA), and as such on the brink of real-world implementation. In the slipstream of these developments increasing commercial initiatives are taking shape. The European Psychiatric Association (EPA) acknowledges both the therapeutic potential of psychedelic substances and the challenges for both research and clinical implementation. Steps need to be taken toward a well-balanced policy based upon sound scientific evidence and research, aiming at safe, ethical responsible integration of psychedelic therapy available for all patients who can potentially benefit.

methodsIn this EPA policy paper, we highlight the potential benefits, and also the challenges of psychedelic treatments, which can be relevant for the future real-world implementation of these treatments.

resultsIn addition to an overview of the current evidence and hypotheses of working mechanisms of psychedelic treatment, this policy paper specifically highlights the importance of the psychosocial components of the treatment as well as the ethical and professional aspects playing a role in real-world implementation.

conclusionsFour recommendations are formulated for further research and clinical implementation.

Indexed as

HallucinogensMental DisordersEuropeHumansPsilocybinPsychiatryHallucinogensPsilocybinDMTLSDmental healthmethodological challengespsilocybinPsychedelicspsychiatric disorders

Identifiers

PMID39791347
PMCPMC11795445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.