Evidence map›Paper›PMID 39791335›Full record

ArticleAnnals of neurology2025

Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1

Elif O Dogan, Sean R Simonini, James Bouley, Alexandra Weiss, Robert H Brown, Nils Henninger

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Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elif O DoganDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Sean R SimoniniDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
James BouleyDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Alexandra WeissDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Robert H BrownDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0001-6062-1528
Nils HenningerDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-3883-5623

Funding

Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal DementiaR21NS131756 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2023 to 2024
$461k
Angel Fund for ALS ResearchMoloney FellowshipNINDS NIH HHS NS131756NINDS NIH HHS R21 NS131756
6 · The paper itself

Abstract

objectiveApproximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.

methodsWe sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1

resultsIn sham injured SOD1

interpretationSARM1-mediated axonal death pathway promotes pathogenesis after TBI in SOD1

Indexed as

Amyotrophic Lateral SclerosisArmadillo Domain ProteinsBrain Injuries, TraumaticCytoskeletal ProteinsSuperoxide Dismutase-1AnimalsDisease Models, AnimalDisease ProgressionFemaleMaleMiceMice, KnockoutMice, TransgenicArmadillo Domain ProteinsCytoskeletal ProteinsSARM1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID39791335
PMCPMC12011539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.