Evidence map›Paper›PMID 39791310›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Metamorphic Proteins to Achieve Conformationally Selective Material Surface Binding.

Kyle B Meerbott, Hassan Monhemi, Lorenzo Travaglini, Artur Sawicki, Sakthirupini Ramamurthy, Joseph M Slocik, Patrick B Dennis, Dominic J Glover, Tiffany R Walsh, Marc R Knecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyle B MeerbottDepartment of Chemistry, University of Miami, Coral Gables, FL, 33146, USA.
Hassan MonhemiInstitute for Frontier Materials, Deakin University, Geelong, VIC, 3216, Australia.
Lorenzo TravagliniSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Artur SawickiSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Sakthirupini RamamurthySchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Joseph M SlocikMaterials and Manufacturing Directorate, Air Force Research Laboratory, Dayton, OH, 45433, USA.
Patrick B DennisMaterials and Manufacturing Directorate, Air Force Research Laboratory, Dayton, OH, 45433, USA.
Dominic J GloverSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0002-6819-4089
Tiffany R WalshInstitute for Frontier Materials, Deakin University, Geelong, VIC, 3216, Australia.ORCID 0000-0002-0233-9484
Marc R KnechtDepartment of Chemistry, University of Miami, Coral Gables, FL, 33146, USA.ORCID 0000-0002-7614-7258

Funding

Army Research Office W911NF-23-1-0365Army Research Office and was accomplished W911NF-23-1-0365
6 · The paper itself

Abstract

The controlled binding of proteins on nanoparticle surfaces remains a grand challenge required for many applications ranging from biomedical to energy storage. The difficulty in achieving this ability arises from the different functional groups of the biomolecule that can adsorb on the nanoparticle surface. While most proteins can only adopt a single structure, metamorphic proteins can access at least two different conformations, which presents intriguing opportunities to exploit such structural variations for binding to nanoparticles. Such effects are examined using calmodulin, a sensing messenger protein, that can adopt two conformations based on Ca

Indexed as

CalmodulinProteinsAdsorptionGoldProtein BindingProtein ConformationSurface PropertiesCalmodulinGoldProteinsassemblyAu bindingcalmodulinmetamorphic proteinnanoparticles

Identifiers

PMID39791310
PMCPMC11840449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.