Evidence map›Paper›PMID 39791215›Full record

ArticleInternational journal of oncology2025

Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines.

Femke Verhees, Imke Demers, Dion Legemaate, Robin Jacobs, Ann Hoeben, Bernd Kremer, Ernst-Jan Speel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Femke Verhees *Department of Otorhinolaryngology, Head and Neck Surgery, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Imke Demers *Department of Pathology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Dion LegemaateDepartment of Pathology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Robin JacobsDepartment of Pathology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Ann HoebenDepartment of Medical Oncology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Bernd KremerDepartment of Otorhinolaryngology, Head and Neck Surgery, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.
Ernst-Jan SpeelDepartment of Pathology, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center, 6229HX Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV)‑positive and -negative head and neck squamous cell carcinoma (HNSCC) are often associated with activation of the phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway due to mutations or amplifications in

Indexed as

Cell ProliferationCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Head and Neck NeoplasmsPapillomavirus InfectionsPiperazinesProto-Oncogene Proteins c-aktSignal TransductionSquamous Cell Carcinoma of Head and NeckTOR Serine-Threonine KinasesAminopyridinesApoptosisCell Line, TumorCell SurvivalHuman Papillomavirus VirusesHumansAminopyridinesCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6MTOR protein, humanpalbociclibPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPiperazinesProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPurinesPyridinesribociclibThiazolesTOR Serine-Threonine Kinasesapoptosiscell cyclecell linecell survivalhead and neck cancerhuman papillomavirus

Identifiers

PMID39791215
PMCPMC11753768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.