Evidence map›Paper›PMID 39791168›Full record

ArticleEndocrine, metabolic & immune disorders drug targets2025

Significance of Serum Magnesium in Parathyroid Hormone Level in Patients with Chronic Kidney Disease.

Jiali Wang, Yongda Lin, Xiutian Chen, Hong-Yan Li, Wenzhuang Tang, Tianbiao Zhou

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, metabolic & immune disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiali WangDepartment of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Yongda LinDepartment of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Xiutian ChenDepartment of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Hong-Yan LiDepartment of Nephrology, Huadu District People's Hospital of Guangzhou, Southern Medical University, Guangzhou, China.
Wenzhuang TangDepartment of Blood Purification, the First Affiliated Hospital of Hainan Medical University, Haikou, China.
Tianbiao ZhouDepartment of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.

Funding

Hainan Province Science and Technology Special Fund ZDYF2021SHFZ081Shantou Medical Health Science and Technology Plan 230509156495997
6 · The paper itself

Abstract

introductionIn chronic kidney disease (CKD) patients, elevated parathyroid hormone (PTH) is linked to cardiovascular mortality and morbidity. Levels of PTH are influenced by serum phosphate (P) and calcium (Ca), but little is known about the impact of magnesium (Mg) on PTH. Hence, this study investigated the relationship between PTH and Mg in peritoneal dialysis (PD) patients and non-dialysis patients from three hospitals in China. MATERIALS AND

methodsThis cross-sectional study included 446 chronic kidney disease stage 5 (CKD5) patients from three hospitals in southern China. PTH was naturally transformed to Ln_PTH for analysis. The chi-square test, Pearson correlation analysis, hierarchical regression analysis, and t-test were used to explore the relationships between Ln_PTH and gender, diabetes history, Mg, P, Ca, albumin (Alb), red blood cells (RBC), hemoglobin (Hb), white blood cells (WBC), and platelet (Plt).

resultsPatients with diabetes mellitus (DM) had lower levels of Ln_PTH in PD (P<0.05) and non-dialysis (P>0.05) patients. Ln_PTH levels were negatively associated with Mg and Ca but positively associated with P and Alb in PD patients (all P<0.05). Ln_PTH levels were negatively associated with age but positively associated with P in non-dialysis patients (all P<0.05).

conclusionThis study demonstrates the negative effect of Mg and diabetes on Ln_PTH levels in CKD5 patients.

Indexed as

MagnesiumParathyroid HormoneRenal Insufficiency, ChronicAdultAgedBiomarkersCalciumChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPeritoneal DialysisBiomarkersCalciumMagnesiumParathyroid HormonePTH protein, humanChronic kidney diseasediabetes.intact parathyroid hormonemagnesiumnon-dialysis patientsperitoneal dialysis patients

Identifiers

PMID39791168
PMCPMC12606617

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