ArticleCureus2024
An Atypical Case of Marchiafava-Bignami Disease in a Young Chronic Alcoholic: Challenges in Diagnosis and Prognosis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel case presentation.Frontiers in molecular biosciences · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 27-year-old male patient with chronic alcohol use disorder was diagnosed with Marchiafava-Bignami disease (MBD) after experiencing an episode of unconsciousness. MRI scans revealed lesions in the corpus callosum and adjacent white matter. Despite prompt initiation of intensive treatment with high-dose thiamine and corticosteroids, the patient only partially recovered, remaining disoriented and exhibiting persistent neurological deficits during follow-up. MBD is a rare condition seen in individuals with chronic alcohol use disorder and malnutrition, often resulting in unfavorable outcomes despite prompt intervention. This case underscores the impact of the patient's young age at the onset of alcohol dependence, a low Glasgow Coma Scale score, and the presence of extracallosal lesions on his overall prognosis. We discuss the pathophysiology, presentation, and treatment. We also describe the role of each prognostic factor of MBD in an unfavourable outcome highlighting the need for a larger study to define various prognostic indicators at presentation and identify appropriate treatment approaches.
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Registered trials
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