ArticleCureus2025
Outcomes and Prognostic Factors in Patients With Untreated Head and Neck Squamous Cell Carcinoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Survival and Prognostic Factors in Unresectable Head and Neck Cancer Patients.Journal of clinical medicine · 2025Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough several studies have reported the treatment prognosis in squamous cell carcinoma of the head and neck, few studies exist on the prognosis and mortality-related risk factors in untreated cases. This study aimed to determine the outcomes of patients with head and neck squamous cell carcinoma who underwent no treatment and investigate the associated factors.
methodsThis retrospective, single-institution study initially included 718 patients with head and neck cancer who visited our hospital between January 2015 and December 2021; 43 untreated patients were included in the final analysis. This study was conducted in Japan, where universal health insurance ensures access to treatment for all citizens.
resultsThe median patient age was 79 years, with a predominance of male patients. The primary reasons for patients being untreated were patient refusal, dementia, and advanced age. The median survival time for untreated patients was 20.5 weeks, with 90% succumbing within one year of their first visit. Univariate analyses showed that an advanced clinical stage (stage IV) was a major determinant of survival. In patients with stage IV disease, living alone or without family support was the sole significant predictor of a poor prognosis.
conclusionsOur results inform healthcare providers about the consequences of not providing treatment and patients regarding treatment choices.
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