Evidence map›Paper›PMID 39790985›Full record

ArticleChemical science2025

Reactivity of a heterobinuclear heme-peroxo-Cu complex with

Sanjib Panda, Suzanne M Adam, Hai Phan, Patrick J Rogler, Pradip Kumar Hota, Joshua R Helms, Brad S Pierce, Gayan B Wijeratne, Kenneth D Karlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanjib PandaDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.ORCID https://orcid.org/0000-0001-6556-8009
Suzanne M AdamDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.
Hai PhanDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.ORCID https://orcid.org/0009-0004-9233-5496
Patrick J RoglerDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.
Pradip Kumar HotaDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.ORCID https://orcid.org/0000-0002-1502-4879
Joshua R HelmsDepartment of Chemistry & Biochemistry, The University of Alabama Tuscaloosa Alabama 35487 USA gwijeratne@ua.edu.
Brad S PierceDepartment of Chemistry & Biochemistry, The University of Alabama Tuscaloosa Alabama 35487 USA gwijeratne@ua.edu.ORCID https://orcid.org/0000-0002-7432-6332
Gayan B WijeratneDepartment of Chemistry & Biochemistry, The University of Alabama Tuscaloosa Alabama 35487 USA gwijeratne@ua.edu.ORCID https://orcid.org/0000-0001-7609-6406
Kenneth D KarlinDepartment of Chemistry, Johns Hopkins University Baltimore Maryland 21218 USA karlin@jhu.edu.ORCID https://orcid.org/0000-0002-5675-7040

Funding

Heme/Copper and Heme/Nonheme Iron O(2) and NO ReactivityR01GM060353 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KARLIN, KENNETH D. · 2000 to 2020
$5.9M
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination ComplexesR35GM139536 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KARLIN, KENNETH D. · 2021 to 2025
$2.9M
NIGMS NIH HHS R01 GM060353NIGMS NIH HHS R35 GM139536
6 · The paper itself

Abstract

In biological systems, heme-copper oxidase (HCO) enzymes play a crucial role in the oxygen reduction reaction (ORR), where the pivotal O-O bond cleavage of the (heme)Fe

Identifiers

PMID39790985
PMCPMC11707526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.