ArticleChemical science2025
Exploring the diffusion of DNA strands into nanoporous structures for establishing a universal electrochemical biosensor.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- An All-in-One Au@CeOAdvanced healthcare materials · 2026Article
- Bioelectroanalytical Technologies for Advancing the Frontiers To Democratize Personalized Desired Health.Analytical chemistry · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of universal electrochemical sensing platforms with high sensitivity and specificity is of great significance for advancing practical disease diagnostic methods and devices. Exploring the structural properties of electrode materials and their interaction with biomolecules is essential to developing novel and distinctive analytical approaches. Here, we innovatively investigated the effect of DNA length and configuration on DNA molecule transfer into the nanostructure of a nanoporous gold (NPG) electrode. The NPG electrode can not only distinguish and quantify short DNA strands but can also prevent the diffusion of long DNA, thereby minimizing or eliminating background interference. Leveraging these findings, we developed a universal DNA-based NPG electrochemical biosensing platform for the detection of different types of biomolecules. As a proof-of-concept, this sensing platform was integrated with nuclease-assisted target-recycling recognition and amplification reactions to achieve sensitive and specific detection of single-stranded DNA, microRNA-21, and carcino-embryonic antigen, with detection limits of 4.09, 27.4, and 0.28 fM, respectively. The demonstrated universality, sensitivity, specificity, and capability for analyzing complex samples ensure a comprehensive and robust detection approach for nucleic acid-based molecular diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.