Analysis of Levels of Vitamin D, Beta-Amyloid 42, Indoxyl Sulfate, and Serum Parathyroid Hormone in Hemodialysis Patients with Cognitive Impairment.

Yuliarni Syafrita, Harnavi Harun, Restu Susanti, Syarif Indra

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Article in Innovations in clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Yuliarni SyafritaProf. Syafrita and Drs. Susanti and Indra are with the Department of Neurology, Faculty of Medicine at Andalas University in Padang, Indonesia.

Harnavi HarunDr. Harun is with the Department of Internal Medicine, Faculty of Medicine at Andalas University in Padang, Indonesia.

Restu SusantiProf. Syafrita and Drs. Susanti and Indra are with the Department of Neurology, Faculty of Medicine at Andalas University in Padang, Indonesia.

Syarif IndraProf. Syafrita and Drs. Susanti and Indra are with the Department of Neurology, Faculty of Medicine at Andalas University in Padang, Indonesia.

Funding

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6 · The paper itself

Abstract

Objective: Cognitive impairment is a recurrent complication in people with chronic kidney disease (CKD), which includes those undergoing hemodialysis (HD). Researchers aimed to analyze vitamin D levels, beta-amyloid 42, indoxyl sulfate, and serum parathyroid hormone (PTH) in patients with cognitive impairment who underwent HD. Design: This comparative, cross-sectional study was conducted at the HD unit of Dr. M Djamil Padang Hospital. This study enrolled 60 patients with CKD who underwent routine HD and 20 normal subjects as controls. In both groups, serum levels of vitamin D, beta-amyloid 42, indoxyl sulfate, and PTH were measured using the enzyme-linked immunosorbent assay method, and cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment neuropsychological test. Results: The mean±standard deviation age of the study subjects was 51.48±11.44 years, with 53.4 percent being male. Vitamin D levels were higher in the control group, compared to the case group ( Conclusion: Lower levels of vitamin D and higher levels of indoxyl sulfate were observed in the group with cognitive impairment when compared to the group without cognitive impairment.

Indexed as

Beta-amyloidcognitive impairmenthemodialysisindoxyl sulfateparathyroid hormonevitamin D

Identifiers

PMID39790902

PMCPMC11709437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.