Evidence map›Paper›PMID 39790637›Full record

ArticleAnnals of thoracic surgery short reports2024

Autoimmune Encephalitis Induced by SARS-CoV-2 Infection Treated with Thymectomy.

Cristian Puerta, Nolan M Winicki, Casandra E Besse, Yu Zhang, Mark Onaitis, Joshua Boys, Jessica Hudson, Patricia A Thistlethwaite

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of thoracic surgery short reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristian PuertaDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Nolan M WinickiDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Casandra E BesseDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Yu ZhangDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Mark OnaitisDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Joshua BoysDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Jessica HudsonDivision of Cardiothoracic Surgery, University of California, San Diego, California.
Patricia A ThistlethwaiteDivision of Cardiothoracic Surgery, University of California, San Diego, California.

Funding

Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
NHLBI NIH HHS R01 HL070852
6 · The paper itself

Abstract

Thymomas have been associated with the generation of paraneoplastic autoantibodies to neurogenic epitopes, collapsin-response-mediator protein-5 receptor (CRMP-5) and alpha-amino-3-hydroxyl-5methyl-4isoxazolepropionic acid receptor (AMPAR), in patients with acute viral infection. We report a patient with thymoma and myasthenia gravis, with SARS-CoV-2 infection, who became comatose secondary to autoimmune encephalitis. Plasmapheresis, high-dose steroids, pyridostigmine, eculizumab, and rituximab did not restore neurologic function. Robotic thymectomy with thymoma resection rendered CRMP-5 and AMPAR antibody titers undetectable and restored neurologic function. Thoracic surgeons should be aware of this rare condition and know that thymectomy is a potential cure for autoimmune-induced encephalitis in patients with thymoma.

Identifiers

PMID39790637
PMCPMC11708430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.