Evidence map›Paper›PMID 39790318›Full record

ArticleAnnals of thoracic surgery short reports2023

Anterior Pericardial Patch Augmentation Repair and Neochord Implantation for Rheumatic Mitral Valves.

Yuanjia Zhu, Shin Yajima, Robert J Wilkerson, Matthew H Park, Joo Young Kim, Pearly K Pandya, Y Joseph Woo

Abstract read
In one paragraph

Article in Annals of thoracic surgery short reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Shin YajimaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Robert J WilkersonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Matthew H ParkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Joo Young KimDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Pearly K PandyaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.

Funding

Biomechanical Optimization of Mitral Valve Repair OperationsR01HL152155 · NHLBI · STANFORD UNIVERSITY · PI WOO, Y JOSEPH · 2020 to 2025
$5.9M
Biomechanical Optimization of Mitral Valve Repair Operations and Annuloplasty Rings for Primary Mitral Valve RegurgitationF32HL158151 · NHLBI · STANFORD UNIVERSITY · PI ZHU, YUANJIA · 2021 to 2022
$144k
NHLBI NIH HHS F32 HL158151NHLBI NIH HHS R01 HL152155
6 · The paper itself

Abstract

Background: The objective of this study was to biomechanically evaluate anterior pericardial patch augmentation repair and the modified technique using neochord implantation in an ex vivo rheumatic mitral valve (RMV) model. Methods: Thermal treatment to the leaflets and chordae and commissure fusion were performed on 4 healthy porcine mitral valves to generate the ex vivo RMV model. Repair was performed by conducting commissural release and anterior pericardial patch augmentation, with or without implantation of 2 neochordae. Hemodynamic, echocardiography, native chordal forces, and high-speed videography data were collected. Results: Compared with baseline, the RMV model successfully generated mitral regurgitation with a regurgitant fraction (RF) of 20.3% ± 9.4% ( Conclusions: Anterior pericardial patch augmentation was effective in repairing RMV by re-establishing coaptation while reducing mean gradient. The modified technique further improved valve hemodynamics and native chordal forces. This study provides biomechanical evidence in favor of anterior pericardial patch augmentation repair and may direct further repair modifications to improve clinical outcomes.

Identifiers

PMID39790318
PMCPMC11708665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.