Evidence map›Paper›PMID 39789822›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025

Development of a Mouse Model of Enthesis-Specific NF-κB Activation.

McKenzie E Sup, Adam C Abraham, Min Kyu M Kim, Stavros Thomopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

McKenzie E SupDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Adam C AbrahamDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Min Kyu M KimDepartment of Orthopaedic Surgery, Columbia University, New York, New York, USA.
Stavros ThomopoulosDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.ORCID 0000-0003-1531-4849

Funding

Tendon Enthesis Development and RegenerationR01AR055580 · NIAMS · WASHINGTON UNIVERSITY · PI THOMOPOULOS, STAVROS · 2009 to 2019
$4.0M
Formation of a functional tendon enthesis during development and healingR01AR080717 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos · 2023 to 2026
$1.9M
NIAMS NIH HHS R01 AR055580NIAMS NIH HHS R01 AR080717The study was funded in part by NIH/NIAMS R01-AR080717.
6 · The paper itself

Abstract

Enthesitis, or inflammation specific to sites in the body where tendon inserts into bone, can arise in isolated joints from overuse or in multiple joints as a complication of an autoimmune condition such as psoriatic arthritis or spondyloarthritis. However, the pathogenesis of enthesitis is not well understood, so treatment strategies are limited. A clinically relevant animal model of enthesitis would allow investigators to determine mechanisms driving the disease and evaluate novel therapies. Therefore, we developed a murine model of inducible enthesis-specific inflammation by constitutively activating the NF-κB pathway in Gli1+ cells. Gli1Cre

Indexed as

Disease Models, AnimalEnthesopathyNF-kappa BAnimalsI-kappa B KinaseMiceMice, TransgenicI-kappa B KinaseNF-kappa BenthesisenthesitisGli1NF‐kBoverusepsoriatic arthritisspondyloarthritis

Identifiers

PMID39789822
PMCPMC11903135

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.