Evidence map›Paper›PMID 39789640›Full record

Trial reportBreast cancer research : BCR2025

Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study.

Elizabeth Mostofsky, Julie E Buring, Steven E Come, Nadine M Tung, Cancan Zhang, Kenneth J Mukamal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05423730 (Effect of Light Alcohol Intake on Sex Hormone Levels Among Postmenopausal Women With ER+ Breast Cancer on Aromatase Inhibitor Therapy), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05423730 nacompletednot on this map

Effect of Light Alcohol Intake on Sex Hormone Levels Among Postmenopausal Women With ER+ Breast Cancer on Aromatase Inhibitor Therapy: The Alcohol and Breast Cancer (ABC) Trial

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2022 to 2023Enrolled23ConditionsER+ Breast Cancer, Breast Cancer, Aromatase InhibitorsArmsWhite Wine, Grape Juice
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth MostofskyDepartment of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Kresge 505-B, Boston, MA, 02115, USA. elm225@mail.harvard.edu.
Julie E BuringDepartment of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Kresge 505-B, Boston, MA, 02115, USA.
Steven E ComeDepartment of Medicine (SEC, NMT, CZ, KJM), Beth Israel Deaconess Medical Center, Harvard Medical, School, Boston, MA, USA.
Nadine M TungCancer Risk and Prevention Program and Breast Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical, School, Boston, MA, USA.
Cancan ZhangDepartment of Medicine (SEC, NMT, CZ, KJM), Beth Israel Deaconess Medical Center, Harvard Medical, School, Boston, MA, USA.
Kenneth J MukamalDepartment of Epidemiology (EM, JEB) and Nutrition (KJM), Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Kresge 505-B, Boston, MA, 02115, USA.

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Alcohol and Breast Cancer: Genetic Interactions and Effects on Aromatase Inhibitor TherapyK01AA027831 · NIAAA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MOSTOFSKY, ELIZABETH · 2019 to 2023
$820k
NCATS NIH HHS UL 1TR002541NIAAA NIH HHS K01 AA027831NIAAA NIH HHS K01AA027831
6 · The paper itself

Abstract

backgroundAlcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through its confirmed ability to increase sex hormone levels. Whether consuming alcohol within the recommended limit of one serving per day increases sex hormone levels among postmenopausal women taking aromatase inhibitors (AI) to inhibit estrogen production remains unknown. Therefore, we compared sex hormone levels following white wine to levels following white grape juice among ER + BC survivors taking AIs.

methodsIn this 10-week randomized controlled two-period crossover trial conducted from September 2022 to July 2023 among 20 postmenopausal women on AIs, we examined within-person changes in sex hormone levels following 3 weeks of 5 ounces of white wine daily versus 3 weeks of 6 ounces of white grape juice daily, with each drinking period preceded by two-week washouts and drinking period sequence allocated by randomization.

resultsAll 20 participants completed the trial. Compared to daily grape juice, daily wine led to decreases in total estradiol (11.1%, 95%confidence interval[CI] -49.8%,57.2%), free estradiol index (0.7%, 95%CI -2%,0.7%), and free estradiol concentration (7.7%, 95%CI -48%, 63.9%) but increases in estrone (13.8%, 95%CI -9.5%,43.1%), dehydroepiandrosterone sulfate (DHEAS; 11.4%, 95%CI -3.3%,28.4%), and testosterone (12.6%, 95%CI -0.8%,27.7%) and decreased sex hormone-binding globulin (SHBG; -2.7%, 95%CI -21.9%,21.2%).

conclusionsFive ounces of white wine daily did not lead to statistically significant increases in estradiol, but it led to changes in other sex hormones suggesting higher BC risk. Whether this level of alcohol intake diminishes AI effectiveness warrants further investigation. TRIALS REGISTRATION: Clinicaltrials.gov NCT05423730 registered June 14, 2022.

Indexed as

Alcohol DrinkingAromatase InhibitorsBreast NeoplasmsCancer SurvivorsCross-Over StudiesGonadal Steroid HormonesPostmenopauseAgedEstradiolFemaleHumansMiddle AgedPilot ProjectsSex Hormone-Binding GlobulinWineAromatase InhibitorsEstradiolGonadal Steroid HormonesSex Hormone-Binding GlobulinAlcoholAromatase inhibitorsCrossover trialEstrogen receptor-positive (ER+) breast cancerEthanolNational Health and Nutrition Examination Surveys (NHANES)Sex hormones

Identifiers

PMID39789640
PMCPMC11720806

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.