ArticleGenome biology2025
Graph pangenome reveals the regulation of malate content in blood-fleshed peach by NAC transcription factors.
Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Multifaceted mechanisms underlying species- and cultivar-associated differential anthocyanin accumulation in fruits.Horticulture research · 2026Article
- Dual regulation of anthocyanins and proanthocyanidins by PpBL and its linkage to acidity in peach.Molecular horticulture · 2026Article
- Transcriptome and Metabolomics Analysis of Sugar and Acid Metabolism Regulated by Different Storage Temperatures in Prunus domestica × armeniaca Fruits.Journal of food science · 2026Article
- Phylogeny-driven pangenome analysis uncovers the genomic landscape of domesticated and wild Armeniaca species.Horticulture research · 2026Article
- From structural pangenomes to functional panomics in plants.Molecular biology and evolution · 2026Review
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Comprehensive Analysis of Malate Accumulation in Peaches in Response to Cold Stress Based on Transcriptomics.Food science & nutrition · 2026Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Genomic resources for crop wild relatives are critical for perennial fruit breeding and conservation.American journal of botany · 2025Review
- Whole-genome sequencing reveals genetic diversity, population structure, and core collection construction in Korean peach (Frontiers in plant science · 2025Article
- Identification and evolutionary analysis of NAC transcription factors inFrontiers in plant science · 2025Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFruit acidity and color are important quality attributes in peaches. Although there are some exceptions, blood-fleshed peaches typically have a sour taste. However, little is known about the genetic variations linking organic acid and color regulation in peaches.
resultsHere, we report a peach graph-based pangenome constructed from sixteen individual genome assemblies, capturing abundant structural variations and 82.3 Mb of sequences absent in the reference genome. Pangenome analysis reveals a long terminal repeat retrotransposon insertion in the promoter of the NAC transcription factor (TF) PpBL in blood-fleshed peaches, which enhances PpBL expression. Genome-wide association study identifies a significant association between PpBL and malate content. Silencing PpBL in peach fruit and ectopic overexpression of PpBL in tomatoes confirm that PpBL is a positive regulator of malate accumulation. Furthermore, we demonstrate that PpBL works synergistically with another NAC TF, PpNAC1, to activate the transcription of the aluminum-activated malate transporter PpALMT4, leading to increased malate content.
conclusionsThese findings, along with previous research showing that PpBL and PpNAC1 also regulate anthocyanin accumulation, explain the red coloration and sour taste in blood-fleshed peach fruits.
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