ArticleNutrition journal2025
Oxidative balance scores and gallstone disease: mediating effects of oxidative stress.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association between weekly sleep duration and gallstones in a US-based adult sample: A cross-sectional study.Medicine · 2025Article
- Association of oxidative balance scores with the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance in the general US adult population: Evidence from NHANES 1999-2018.The Journal of international medical research · 2025Article
- Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management.Cureus · 2025Review
- Association between oxidative balance score and gallstone in US adults: a cross-sectional study.Frontiers in aging · 2025Article
- Association between serum carotenoid levels and gallstones in adults: a cross-sectional study using the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones.Frontiers in nutrition · 2025Article
- Age-dependent association between lifestyle oxidative balance score and bone mineral density in children and adolescents: evidence from the NHANES 2015-2018.Frontiers in physiology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundGallstone disease (GSD) is a prevalent gastrointestinal disorder, few studies have examined the combined effects of dietary and lifestyle factors on GSD. This study aims to investigate the relationship between oxidative balance score (OBS) and GSD, and explores the potential mediating role of oxidative stress.
methodsCross-sectional data from 6,196 participants in the NHANES 2017-2020 were analyzed. OBS, encompassing 16 dietary and 4 lifestyle factors, was assessed alongside GSD prevalence. Weighted multivariate logistic regression, restricted cubic spline (RCS) analysis were used to explore the relationship between OBS and GSD and mediation analysis was used to test the indirect effect of oxidative stress indicators. Subgroup analysis and sensitivity analysis were used to determine the stability of results.
resultsA higher OBS was significantly associated with a reduced risk of GSD (OR: 0.701, 95% CI: 0.492-0.999, P < 0.05). RCS analysis revealed a linear association between OBS and GSD risk. Mediation analysis indicated significant mediating effects of albumin and uric acid, with a combined mediation proportion of 19.540% (P < 0.05). Subgroup analysis revealed differences and interrelationships based on education level, providing additional insights into the relationship between OBS and GSD and sensitivity analysis confirmed the stability of these associations.
conclusionsA higher OBS is associated with a reduced risk of GSD, especially among higher education levels groups, and albumin, uric acid may act as mediators of this association. These findings underscore the potential role of oxidative stress in GSD and the significance of maintaining a healthy diet and lifestyle to decrease GSD risk.
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