Evidence map›Paper›PMID 39789542›Full record

ArticleBMC women's health2025

Factors influencing endometrial receptivity in women with recurrent implantation failure.

Katarzyna Opuchlik, Katarzyna Pankiewicz, Piotr Pierzyński, Janusz Sierdziński, Elina Aleksejeva, Andres Salumets, Tadeusz Issat, Piotr Laudański

Abstract read
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In one paragraph

Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katarzyna Opuchlik *Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland. katarzyna.opuchlik@imid.med.pl.
Katarzyna Pankiewicz *Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland.
Piotr PierzyńskiOVIklinika Infertility Center, Połczyńska 31, Warsaw, 01-377, Poland.
Janusz SierdzińskiDepartment of Medical Informatics and Telemedicine, Medical University of Warsaw, Warsaw, Poland.
Elina AleksejevaDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Andres SalumetsDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Tadeusz IssatDepartment of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland.
Piotr LaudańskiOVIklinika Infertility Center, Połczyńska 31, Warsaw, 01-377, Poland.

Funding

Estonian Research Council PRG1076Horizon 2020 innovation grant ERIN, grant no. EU952516Polish Ministry of Science and Higher Education OPK 510-07-31
6 · The paper itself

Abstract

backgroundEmbryo implantation involves two key elements: a good quality embryo and receptive endometrium. Endometrial receptivity abnormalities are known as one of the possible causes of recurrent implantation failure (RIF), especially when the embryo is euploid. This study was aimed to evaluate the impact of age and other clinical factors on endometrial receptivity in women with RIF.

methods68 women with RIF (defined as at least three unsuccessful transfers of good quality embryo of at least 1BB category of blastocysts) and 49 controls (women undergoing IVF treatment because of idiopathic infertility or male factor) were included to the study. After preparation of the endometrium by the hormone replacement therapy endometrial biopsies were taken from each patient and sequenced with beREADY test TAC targeting 67 biomarker genes for endometrial receptivity. Depending on the test result patients were classified into one of four different groups: pre-receptive (n = 16), early-receptive (n = 54), receptive (n = 44) and late-receptive (n = 3).

resultsIn women with RIF pre-receptive endometrium has been detected substantially more often than in controls - 13 (19,1%) vs. 3 (6,1%) patients (p = 0,043). Early-receptive endometrium was diagnosed in the majority of patients with idiopathic infertility - 12 (66.7%) vs. 6 (33.3%) women (p = 0.042) and with polycystic ovary syndrome (PCOS) - 12 (70,6%) vs. 3 (17.7%) women (p = 0,0447). We found significant association between abnormal endometrial receptivity and patient's age and duration of infertility. Young women were diagnosed significantly more often as normal or late-receptive, whereas older women with longer history of infertility as early-receptive and pre-receptive.

conclusionsIn patients with RIF in comparison to other women undergoing IVF procedures, patient's age and infertility duration are the most important factors related to endometrial receptivity abnormalities, indicating that older women with a longer history of infertility may benefit the most from endometrial receptivity testing.

trial registrationNot applicable.

Indexed as

Embryo ImplantationEmbryo TransferEndometriumFertilization in VitroInfertility, FemaleAdultAge FactorsCase-Control StudiesFemaleHumansPregnancyTreatment FailureChronic endometritisEndometrial receptivityPersonalized embryo transferRecurrent implantation failureWindow of implantation

Identifiers

PMID39789542
PMCPMC11715555

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.