Evidence map›Paper›PMID 39789409›Full record

ArticleNeurochemical research2025

Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling.

Zila Martinez-Lozada, Alain M Guillem, Isabella Song, Michael V Gonzalez, Hajime Takano, Esha Parikh, Jeffrey D Rothstein, Mary E Putt, Michael B Robinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zila Martinez-LozadaDepartments of Pediatrics and Systems Pharmacology & Translational Therapeutics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 19104-4318, USA. zmartinezlozada@icloud.com.ORCID http://orcid.org/0000-0002-5148-280X
Alain M GuillemDepartments of Pediatrics and Systems Pharmacology & Translational Therapeutics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 19104-4318, USA.
Isabella SongDepartments of Pediatrics and Systems Pharmacology & Translational Therapeutics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 19104-4318, USA.
Michael V GonzalezCenter for Cytokine Storm Treatment & Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hajime TakanoDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Esha ParikhDepartments of Pediatrics and Systems Pharmacology & Translational Therapeutics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 19104-4318, USA.
Jeffrey D RothsteinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mary E PuttDepartment of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Michael B RobinsonDepartments of Pediatrics and Systems Pharmacology & Translational Therapeutics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 19104-4318, USA. robinson@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-0162-2218

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
Regulation of glutamate transport in astrocyte subtypes and in ALSR01NS092067 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBINSON, MICHAEL BYRNE, ROTHSTEIN, JEFFREY D · 2015 to 2019
$2.3M
Astroglial Glutamate Transporters, Calcium, and MitochondriaR01NS106693 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBINSON, MICHAEL BYRNE · 2018 to 2021
$2.0M
Children's Hospital of Philadelphia 7260700623-18NICHD NIH HHS P50 HD105354NICHD NIH HHS U54 HD086984NIH HHS HD086984NIH HHS NS092067NINDS NIH HHS R01 NS092067NINDS NIH HHS R01 NS106693
6 · The paper itself

Abstract

In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of the entire glutamate transporter 1 (GLT1) gene, eGFP is found in all 'adult' cortical astrocytes. However, when 8.3 kilobases of the human GLT1/EAAT2 promoter is used to control expression of tdTomato (tdT), tdT is only found in a subpopulation of these eGFP-expressing astrocytes. The eGFP mice have been used to define mechanisms of transcriptional regulation using astrocytes cultured from cortex of 1-3 day old mice. Using the same cultures, we were never able to induce tdT

Indexed as

AstrocytesCell MovementGlutamic AcidAnimalsAnimals, NewbornExcitatory Amino Acid Transporter 2Green Fluorescent ProteinsLateral VentriclesMiceMice, Inbred C57BLMice, TransgenicSignal TransductionStem CellsExcitatory Amino Acid Transporter 2Glutamic AcidGreen Fluorescent ProteinsAnd glutamate transportAstrocyte precursor cellsAstrocytesDevelopmentGlutamate receptorMigration

Identifiers

PMID39789409
PMCPMC11717811

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.