ArticleCommunications chemistry2025
Real-time visualisation of fast nanoscale processes during liquid reagent mixing by liquid cell transmission electron microscopy.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Atomistic Mechanisms Triggered by Joule Heating Effects in Metallic Cu-Bi Nanowires for Spintronics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Nanoscale Characterization of Nanomaterial-Based Systems: Mechanisms, Experimental Methods, and Challenges in Probing Corrosion, Mechanical, and Tribological Properties.Nanomaterials (Basel, Switzerland) · 2025Review
- 25+ Years of Research on Nonphotochemical Laser-Induced Nucleation (NPLIN).Crystal growth & design · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liquid cell transmission electron microscopy (LCTEM) is a powerful technique for investigating crystallisation dynamics with nanometre spatial resolution. However, probing phenomena occurring in liquids while mixing two precursor solutions has proven extremely challenging, requiring sophisticated liquid cell designs. Here, we demonstrate that introducing and withdrawing solvents in sequence makes it possible to maintain optimal imaging conditions while mixing liquids in a commercial liquid cell. We succeeded in visualising a fast nanoscale crystallisation mechanism when an organic molecule of R-BINOL-CN dissolved in chloroform interacts with methanol. The scanning transmission electron microscopy images recorded in real-time during the interaction of the two volatile solvents reveal the formation of chain-like structures of R-BINOL-CN particles, whereas they coalesce to form single large particles when methanol is absent. Our approach of mixing liquids establishes a platform for novel LCTEM studies of a wide range of electron-beam-sensitive materials, including drug molecules, polymers and molecular amphiphiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.