Evidence map›Paper›PMID 39789326›Full record

ArticleCalcified tissue international2025

Administration of Bisphosphonate Preparations to Mice with Mild-type Hypophosphatasia Reduces the Quality of Spontaneous Locomotor Activity.

Aki Nakamura-Takahashi, Satoshi Ishizuka, Kengo Hirai, Satoru Matsunaga, Norio Kasahara, Seikou Shintani, Shinichi Abe, Masataka Kasahara

Abstract read
In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification of hypophosphatasia in adults with persistent hypophosphatasemia: clinical-genetic characterization and a validated diagnostic tool.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aki Nakamura-TakahashiDepartment of Pharmacology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan. atakahashi@tdc.ac.jp.
Satoshi IshizukaDepartment of Pharmacology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Kengo HiraiDepartment of Pediatric Dentistry, Tokyo Dental College, Tokyo, Japan.
Satoru MatsunagaTokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan.
Norio KasaharaTokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan.
Seikou ShintaniTokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan.
Shinichi AbeTokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan.
Masataka KasaharaDepartment of Pharmacology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan. mkasahar@tdc.ac.jp.

Funding

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Tokyo Dental College Well-being ProjectJSPS KAKENHI 23K15986JSPS KAKENHI JP19K18970JSPS KAKENHI JP22K17026
6 · The paper itself

Abstract

Hypophosphatasia (HPP) is a congenital bone disease caused by tissue-nonspecific mutations in the alkaline phosphatase gene. It is classified into six types: severe perinatal, benign prenatal, infantile, pediatric, adult, and odonto. HPP with femoral hypoplasia on fetal ultrasonography, seizures, or early loss of primary teeth can be easily diagnosed. In contrast, pediatric, adult, and odonto types of HPP over 4 years of age are less likely to be diagnosed because they do not have typical symptoms. Consequently, it may be misdiagnosed as common osteoporosis, and treatments incompatible with HPP may be implemented. The purpose of this study was to analyze the effects of bisphosphonate preparations administration on the femur of Akp2

Indexed as

DiphosphonatesDisease Models, AnimalHypophosphatasiaLocomotionAlkaline PhosphataseAnimalsBone Density Conservation AgentsFemurMiceZoledronic AcidAlkaline PhosphataseBone Density Conservation AgentsDiphosphonatesZoledronic AcidBisphosphonateBone structureFemoral head cartilageHypophosphatasiaLocomotor activity

Identifiers

PMID39789326
PMCPMC11717816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.