ArticleNeurosurgical review2025
ADC histogram analysis of tumor-infiltrating CD8+ T cell levels in meningioma.
Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Whole-lesion iodine map histogram analysis combined with focal ROI iodine concentrations for preoperative prediction of cytokeratin 19-positive hepatocellular carcinoma.Abdominal radiology (New York) · 2026Article
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11 authors.
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Abstract
To investigate the value of preoperative MRI features and ADC histogram analysis for evaluating tumor-infiltrating CD8+ T cells in meningiomas. In this single-center cross-sectional study, we conducted a retrospective analysis of clinical, imaging, and pathological data from 84 patients with meningioma and performed immunohistochemical staining to quantitatively evaluate CD8+ T cells. Using X-Tile software, we divided the patients into high-and low-CD8+ T cells groups based on cut-off values. Furthermore, we compared the clinical and MRI features between the two groups and assessed the predictive value of significant parameters by plotting ROC curves. Additionally, Spearman's analysis was used to examine the association between ADC histogram parameters and CD8+ T cells. The level of tumor-infiltrating CD8+ T cells was found to have a negative correlation with recurrence in patients with meningiomas (r=-0.235, p = 0.031). No statistically significant differences were found in clinical and conventional MRI features between the two groups (all p > 0.05). Conversely, among the ADC histogram parameters, the coefficient of variation (CV), Perc.01, Perc.05, Perc.10, and Perc.25 showed statistically significant differences between the two groups (all p < 0.05) and combined ADC histogram parameters had the highest AUC (0.791; 95%CI (0.689-0.872)). Additionally, we observed a positive correlation between Perc.01, Perc.05, Perc.10 and CD8+ T cells (p < 0.05), the CV and variance was negatively correlated with the levels of CD8+ T cells (p < 0.05). ADC histogram analysis can be used as an imaging tool to preoperatively assess CD8+ T cells in patients with meningioma, and found a certain correlation between them.
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