ArticleAnnals of surgical oncology2025
The Necessity of Lymphadenectomy for Non-Small Cell Lung Cancer Smaller Than 6 mm in Solid Size.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and management outcomes of chylothorax after pulmonary resection for primary lung cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Risk-adapted nodal evaluation in stage IA non-small cell lung cancer: a population-based competing-risk analysis.World journal of surgical oncology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the necessity of lymph node sampling for specific non-small cell lung cancer (NSCLC).
methodsPatients with small-size (≤2 cm) NSCLC who underwent surgical resection between 2009 and 2022 were retrospectively screened. The characteristics of patients with nodal metastasis were demonstrated. For selected patients, the perioperative and long-term outcomes with and without lymphadenectomy were compared.
resultsOf the 2713 patients enrolled in this study, 75 (2.76 %) had involvement of nodules with a minimum solid size of 6 mm. No patient with pure ground glass opacity (0/945) had nodal metastasis, whereas 14 patients with part-solid nodules (14/1260, 1.11 %) and 61 patients with solid nodules (61/508, 12.01 %) had nodal involvement. Patients who had NSCLC with solid components smaller than 6 mm (n=1588) had no nodal metastasis. Of these patients, 339 underwent sublobar resection without lymphadenectomy (SRN0), 1056 received sublobar resection with lymphadenectomy (SRN1), and 190 received lobectomy with lymphadenectomy (LRN1). The patients with SRN0 had a shorter operating time, less volume of drainage, a lower incidence of chylothorax (0 % vs 0.6 % vs. 2.1 %; P = 0.012) and air leakage, as well as a shorter postoperative hospital stay (3 vs. 4 vs. 4 days; P < 0.001) than those with SRN1 or LRN1. The 5-year recurrence-free survival was 100 % for the patients with SRN0, 99.2 % for those with SRN1, and 98.5 % for those with LRN1 (P = 0.370).
conclusionLymphadenectomy may be unnecessary for NSCLC smaller than 6 mm in solid size. Sublobar resection without lymphadenectomy had favorable effects on postoperative complications and fast recovery with no compromise of long-term outcomes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.