ArticleMycopathologia2025
Whole Genome Sequence Analysis of Terbinafine Resistant and Susceptible Trichophyton Isolates from Human and Animal Origin.
Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- The emergence of superficial dermatophytosis due toJournal of clinical microbiology · 2026Article
- Targeted Screening to PredictJournal of fungi (Basel, Switzerland) · 2026Article
- The Evolving Landscape of Dermatophytosis in the UAE: Trichophyton indotineae and Related Genotypes.Mycoses · 2026Article
- Global Emergence ofInfection and drug resistance · 2026Review
- Trichophyton indotineae: Epidemiology, antifungal resistance and antifungal stewardship strategies.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- First report ofMedical mycology case reports · 2025Article
- Genomic epidemiology and antifungal resistance of emergingEmerging microbes & infections · 2025Article
- Integrating Machine Learning and Molecular Methods forPathogens (Basel, Switzerland) · 2025Article
- [Trichophyton mentagrophytes ITS genotype VIII/Trichophyton indotineae in Germany-revisit after 5 years].Dermatologie (Heidelberg, Germany) · 2025Article
- Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025Review
- The Rise of Antifungal-Resistant Dermatophyte Infections: What Dermatologists Need to Know.Cutis · 2025Review
- Global Dermatophyte Infections Linked to Human and Animal Health: A Scoping Review.Microorganisms · 2025Review
- Emerging Human Health Problems Caused by Pathogenic and Immuno-activating Fungi.Current topics in microbiology and immunology · 2025Review
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11 authors.
Funding
Abstract
Trichophyton indotineae, first identified in India, has increasingly been reported in Asia, the Middle East, Europe, and recently in the USA. The global spread of terbinafine-resistant T. indotineae underscores the urgency of the issue. With its ability for human-to-human transmission, it can be considered anthropophilic. However, its highly virulent nature suggests a possible link to zoophilic species, raising the potential for disease transmission from animals. In this study, we have performed whole genome sequencing (WGS) of terbinafine susceptible and resistant Trichophyton species from animal and human origin to understand transmission dynamics of this species. Thirteen isolates of Trichophyton spp. from human (n = 9) and canine (n = 4) origin, respectively from Chandigarh and Bareilly, India, were included in this study. Isolate identification based on ITS extracted from WGS data identified six T. indotineae (ITS genotype VIII) and seven T. interdigitale (ITS genotype II) isolates. WGS single nucleotide polymorhpism (SNP) analysis separated the isolates into two distinct groups, T. indotineae and T. interdigitale and showed the clonal nature of both species. For both species, low SNP differences between isolates from humans and dogs were observed as well as low differences between isolates from Chandigarh and Bareilly, cities >350 km apart from each other. These findings suggest zoonotic transmission, next to fast spread across large distances. The T. indotineae terbinafine-resistant strains exhibited the SQLE
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