Evidence map›Paper›PMID 39789238›Full record

ArticleMolecular neurobiology2025

FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT

Qian Yan, Xiao-Jun Li, Qi-Qi Wang, Wei Jia, Shu-Ling Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian YanSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Xiao-Jun LiSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Qi-Qi WangSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Wei JiaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Shu-Ling WangSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. jingelwang@gzucm.edu.cn.

Funding

National Natural Sciences Foundation of China 82174257
6 · The paper itself

Abstract

Approaches of promoting a neural milieu permissive for plasticity and resilience against neuronal injury are important strategies for the treatment of a range of neurological disorders. Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective against various mental diseases. However, the underlying molecular mechanisms remain elusive. Here, we report a study of the neuroprotective effects of FGF21 by promoting 5-HT

Indexed as

Fibroblast Growth FactorsMAP Kinase Signaling SystemNeuroprotective AgentsReceptor, Fibroblast Growth Factor, Type 1Receptor, Serotonin, 5-HT1AAnimalsGlutamic AcidHippocampusHumansMaleMAP Kinase Kinase 1MiceMice, Inbred C57BLPhosphorylationFgfr1 protein, mousefibroblast growth factor 21Fibroblast Growth FactorsGlutamic AcidMAP Kinase Kinase 1Neuroprotective AgentsReceptor, Fibroblast Growth Factor, Type 1Receptor, Serotonin, 5-HT1AFGFR1-5-HT1AR heteromerNeurological damageNeuroprotection

Identifiers

PMID39789238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.