Evidence map›Paper›PMID 39789174›Full record

ArticleScientific reports2025

UW supplementation with AP39 improves liver viability following static cold storage.

McLean Taggart, Saige Holkup, Alexandra Tchir, Mohammadreza Mojoudi, Arnaud Lyon, Madeeha Hassan, Christopher Taveras, Ozge Sila Ozgur, James F Markmann, Heidi Yeh and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

McLean TaggartCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Saige HolkupCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alexandra TchirCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mohammadreza MojoudiCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Arnaud LyonCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Madeeha HassanCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Christopher TaverasCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ozge Sila OzgurCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James F MarkmannPenn Transplant Institute, University of Pennsylvania, Philadelphia, PA, USA.
Heidi YehCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Korkut Uygun *Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. KUYGUN@mgh.harvard.edu.
Alban Longchamp *Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. alongchamp@mgh.harvard.edu.

Funding

TRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1998 to 2024
$6.4M
High subzero preservation of liver for transplantationR01DK114506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET, UYGUN, KORKUT · 2017 to 2025
$4.4M
Metabolic Modeling for Cadaveric Organ ResuscitationR01DK096075 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UYGUN, KORKUT, YEH, HEIDI · 2012 to 2022
$3.9M
Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservationR01EB028782 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Biju Parekkadan, Korkut Uygun · 2021 to 2026
$3.1M
NIAID NIH HHS T32 AI007529NIBIB NIH HHS R01 EB028782NIDDK NIH HHS R01 DK096075NIDDK NIH HHS R01 DK114506
6 · The paper itself

Abstract

Static cold storage of donor livers at 4 °C incompletely arrests metabolism, ultimately leading to decreases in ATP levels, oxidative stress, cell death, and organ failure. Hydrogen Sulfide (H

Indexed as

Cold TemperatureLiverOrgan PreservationOrgan Preservation SolutionsTissue SurvivalAdenosineAllopurinolAnimalsApoptosisFemaleGlutathioneHepatocytesInsulinOrganophosphorus CompoundsPerfusionRaffinoseAdenosineAllopurinolAP39 compoundGlutathioneInsulinOrganophosphorus CompoundsOrgan Preservation SolutionsRaffinoseThionesUniversity of Wisconsin-lactobionate solution

Identifiers

PMID39789174
PMCPMC11718015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.