ArticleScientific reports2025
New insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biogenic Zinc Oxide Nanoparticles for Skin Disorders: Mechanistic Insights, Translational Challenges, and Future Prospects.Biological trace element research · 2026Review
- Linking Ghrelin Elevation to Reproductive Dysfunction: Insights from Feed-Restricted Male Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutaraldehyde (GLU) is mainly used in medicine by healthcare workers during infection control as a chemical disinfectant. It has been linked to numerous health hazards that range from asthma to irritation of the eye to contact dermatitis. Citrullus colocynthis (C.C.) is utilized as a supplement to combat a range of health-related problems. This study aimed to assess the effectiveness of locally applied Citrullus colocynthis extract and Citrullus colocynthis loaded with ZnONPs against dermatitis caused by the disinfectant glutaraldehyde (2%).The female mice were divided into five groups (G1, G2, G3, G4, and G5). Group 1 was used as a control. The other 4 groups (2,3,4,and 5) were sprayed with 2% GLU (2 mg/kg body weight), and the other groups (3,4,and 5) were subjected to local application of natural products (Citrullus colocynthis extract cream, ZnONP cream, and Citrullus colocynthis loaded on ZnONP cream), respectively. Each experimental animal was followed for 5 days per week for 30 days.Our findings revealed that GLU-induced dermatitis via the upregulation of TNF-α, IL-1b, NFkb 1, and ptgs2 mRNA expression and the downregulation of TGFB1 mRNA expression caused oxidative stress and altered the biochemical markers and histological appearance. However, these effects were improved by the ZnONPs, C.C. extract, and C.C.-ZnONPs.Local application of Citrullus colocynthis ZnONPs and ZnONPs had preventive effects against GLU-induced dermatitis through the suppression of oxidative stress and inflammatory markers and the enhancement of antioxidants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.