Evidence map›Paper›PMID 39789019›Full record

ArticleScientific reports2025

The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly.

Makoto Kawai, S M Hadi Hosseini, Casey Buck, Rosy Karna, Kai Ayinde Parker-Fong, Pahnwat Tonya Taweesedt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Makoto Kawai *Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA. mkawai71@stanford.edu.
S M Hadi Hosseini *Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Casey BuckDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Rosy KarnaDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Kai Ayinde Parker-FongDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Pahnwat Tonya TaweesedtDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.

Funding

Microstructural changes in gray and white matter in aging and ADR01AG073362 · NIA · STANFORD UNIVERSITY · PI Hadi Hosseini · 2022 to 2026
$3.7M
Interactive Effects of Aging and AD on Brain NetworksR01AG072470 · NIA · STANFORD UNIVERSITY · PI Hadi Hosseini · 2022 to 2026
$2.9M
Cortical Hemodynamism and Oxygenation During Sleep and Cognition: Window to Cognitive Impairment and Neurodegeneration in AgingK23AG053465 · NIA · STANFORD UNIVERSITY · PI KAWAI, MAKOTO · 2017 to 2022
$1.1M
A Novel Neuromonitoring Guided Cognitive Intervention for Targeted Enhancement of Working MemoryR61MH119289 · NIMH · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2019 to 2021
$787k
The influence of multi-domain cognitive training on large-scale structural and functional brain networks in MCIK25AG050759 · NIA · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2016 to 2020
$739k
A Wearable Optical Imaging System for Daily Monitoring of Prefrontal Activity in ADHDR21MH123873 · NIMH · STANFORD UNIVERSITY · PI BOWDEN, AUDREY KYNSELLA, HOSSEINI, HADI · 2020 to 2020
$443k
Development of a cost-effective and neurobiologically valid VR assessment tool for early detection of ADR21AG073973 · NIA · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2021 to 2022
$433k
Multi-dimensional network framework for AD detection and progressionR21AG064263 · NIA · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2019 to 2020
$430k
Eunice Kennedy Shriver National Institute of Child Health and Human Development P50HD10986102National institute on aging, United States K23AG053465National institute on aging, United States K25AG050759National institute on aging, United States R01AG072470National institute on aging, United States R01AG073362National institute on aging, United States R21AG064263National institute on aging, United States R21AG073973NIA NIH HHS K23 AG053465NIA NIH HHS K25 AG050759NIA NIH HHS R01 AG072470NIA NIH HHS R01 AG073362NIA NIH HHS R21 AG064263NIA NIH HHS R21 AG073973NIMH NIH HHS R21AG073973NIMH NIH HHS R21 MH123873NIMH NIH HHS R21MH123873NIMH NIH HHS R61 MH119289NIMH NIH HHS R61MH119289
6 · The paper itself

Abstract

backgroundIntermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable.

methodsFifty-two community-dwelling healthy older adults (28 women) were recruited. All participants underwent neuropsychiatric evaluations, simultaneous ambulatory polysomnography (PSG), and near-infrared spectroscopy (NIRS) recordings. We quantified the average coherence between oxy-Hb and SpO

resultsThe mean (SD) coherence of oxy-Hb and SpO

conclusionThis is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO

Indexed as

BrainCognitionSleep Apnea SyndromesSpectroscopy, Near-InfraredAgedCognitive DysfunctionFemaleHumansHypoxiaMaleMiddle AgedOxygenOxyhemoglobinsPolysomnographyOxygenOxyhemoglobins

Identifiers

PMID39789019
PMCPMC11718048

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.