Evidence map›Paper›PMID 39788930›Full record

ArticleNature communications2025

Spatial control of doping in conducting polymers enables complementary, conformable, implantable internal ion-gated organic electrochemical transistors.

Duncan J Wisniewski, Liang Ma, Onni J Rauhala, Claudia Cea, Zifang Zhao, Alexander Ranschaert, Jennifer N Gelinas, Dion Khodagholy

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Nanostructured Ion Conductor Design for Highly Efficient Ion Transport.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Implantable bioelectronic outlet.Science advances · 2026
    Article
  4. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  5. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Duncan J WisniewskiDepartment of Electrical Engineering, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-5405-1258
Liang MaDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Onni J RauhalaDepartment of Electrical Engineering, Columbia University, New York, NY, USA.
Claudia CeaDepartment of Electrical Engineering, Columbia University, New York, NY, USA.
Zifang ZhaoDepartment of Electrical Engineering, Columbia University, New York, NY, USA.
Alexander RanschaertDepartment of Electrical Engineering, Columbia University, New York, NY, USA.
Jennifer N GelinasDepartment of Biomedical Engineering, Columbia University, New York, NY, USA. gelinasj@hs.uci.edu.
Dion KhodagholyDepartment of Electrical Engineering, University of California, Irvine, CA, USA. dion.kh@uci.edu.ORCID http://orcid.org/0000-0003-0805-4612

Funding

Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe EpilepsyR01NS118091 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Jennifer Gelinas · 2021 to 2026
$2.0M
Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)RF1NS128669 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KHODAGHOLY, DION · 2022 to 2022
$1.5M
Conformable, Expandable Neural Interface Device for the developing brainR21EY032381 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GELINAS, JENNIFER, KHODAGHOLY, DION · 2021 to 2022
$463k
NEI NIH HHS R21 EY032381NINDS NIH HHS R01 NS118091NINDS NIH HHS RF1 NS128669
6 · The paper itself

Abstract

Complementary transistors are critical for circuits with compatible input/output signal dynamic range and polarity. Organic electronics offer biocompatibility and conformability; however, generation of complementary organic transistors requires introduction of separate materials with inadequate stability and potential for tissue toxicity, limiting their use in biomedical applications. Here, we discovered that introduction of source/drain contact asymmetry enables spatial control of de/doping and creation of single-material complementary organic transistors from a variety of conducting polymers of both carrier types. When integrated with the vertical channel design and internal ion reservoirs of internal ion-gated organic electrochemical transistors, we produced matched complementary IGTs (cIGTs) that formed high-performance conformable amplifiers with 200 V/V uniform gain and 2 MHz bandwidth. These amplifiers showed long-term in vivo stability, and their miniaturized biocompatible design allowed implantation in developing rodents to monitor network maturation. cIGTs expand the use of organic electronics in standard circuit designs and enhance their biomedical potential.

Indexed as

PolymersTransistors, ElectronicAnimalsBiocompatible MaterialsElectrochemical TechniquesEquipment DesignProstheses and ImplantsRatsBiocompatible MaterialsPolymers

Identifiers

PMID39788930
PMCPMC11717955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.