Evidence map›Paper›PMID 39788739›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older

Larissa Fischer, Eóin N Molloy, Alexa Pichet Binette, Niklas Vockert, Jonas Marquardt, Andrea Pacha Pilar, Michael C Kreissl, Jordana Remz, Jennifer Tremblay-Mercier, Judes Poirier and 4 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Larissa FischerGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany larissa.fischer@dzne.de anne.maass@dzne.de sylvia.villeneuve@mcgill.ca.ORCID 0009-0001-9936-2954
Eóin N MolloyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany.ORCID 0000-0002-7804-2214
Alexa Pichet BinetteClinical Memory Research, Faculty of Medicine, Lund University, Lund 223 62, Sweden.ORCID 0000-0001-5218-3337
Niklas VockertGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany.ORCID 0000-0001-5915-2517
Jonas MarquardtGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany.ORCID 0000-0002-4796-0864
Andrea Pacha PilarInstitute for Biology, Otto von Guericke University Magdeburg, Magdeburg 39120, Germany.
Michael C KreisslDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg 39120, Germany.ORCID 0000-0001-5905-6015
Jordana RemzDouglas Mental Health University Institute Research Centre, McGill University, Montréal H4H 1R3, Canada.
Jennifer Tremblay-MercierDouglas Mental Health University Institute Research Centre, McGill University, Montréal H4H 1R3, Canada.
Judes PoirierDouglas Mental Health University Institute Research Centre, McGill University, Montréal H4H 1R3, Canada.ORCID 0000-0002-8018-4545
Maria Natasha RajahDouglas Mental Health University Institute Research Centre, McGill University, Montréal H4H 1R3, Canada.
Sylvia VilleneuveDouglas Mental Health University Institute Research Centre, McGill University, Montréal H4H 1R3, Canada larissa.fischer@dzne.de anne.maass@dzne.de sylvia.villeneuve@mcgill.ca.ORCID 0000-0003-2338-0467
PREVENT-AD Research Group
Anne MaassGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany larissa.fischer@dzne.de anne.maass@dzne.de sylvia.villeneuve@mcgill.ca.ORCID 0000-0002-7889-795X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer's disease (AD) are lacking and the relationship to the Apolipoprotein-E (

Indexed as

Amyloid beta-PeptidesApolipoprotein E4CognitionMental RecallParietal LobeAgedAlzheimer DiseaseFemaleHeterozygoteHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesApolipoprotein E4tau ProteinsamyloidAPOE4episodic memory retrievalfunctional hyperactivitymultimodal neuroimagingprecuneus

Identifiers

PMID39788739
PMCPMC11800745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.