ArticleAJNR. American journal of neuroradiology2025
Circle of Willis Variants and Their Association with Outcome after Successful Revascularization of Anterior Large Vessel Occlusion.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Human cerebral arterial morphogenesis explored by 3D microscopic imaging of cleared embryos: Bridging the gap between embryonic and adult anatomy.Journal of anatomy · 2026Article
- CFD-driven optimization and experimental validation of venturi-based thrombectomy devices in a circle of willis.Scientific reports · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeLeptomeningeal collaterals have been associated with better outcomes in large-vessel stroke, but little is known about how the circle of Willis (CoW) collaterals affect stroke outcomes. We aimed to determine the relationship between 3 anatomically distinct CoW subtypes and 90-day outcomes in patients with acute ischemic stroke after successful revascularization via endovascular thrombectomy (EVT). MATERIALS AND
methodsWe performed a retrospective analysis of patients treated with successful EVT for large-vessel occlusion at a comprehensive stroke center between May 2016 and November 2023. The CoW anatomy was trichotomized by using baseline CT angiography as follows: 1) complete circle of Willis (C-CoW), 2) nonisolating incomplete circle of Willis (NI-CoW), and 3) isolating incomplete circle of Willis (I-CoW). χ
resultsA total of 465 patients were included in the analysis. Multivariable logistic regression analysis demonstrated a significant association between I-CoW and 90-day mRS compared with NI-CoW (OR [95% CI], 1.83 [1.08-3.09];
conclusionsCoW variants are associated with functional and mortality outcomes in patients treated with EVT for anterior circulation large vessel occlusion. Further research is needed to determine how CoW vessel anatomy may impact clinical assessment, triage, and treatment in acute ischemic stroke.
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