Evidence map›Paper›PMID 39788537›Full record

SynthesisAmerican journal of perinatology2025

Urinary Acetaminophen Metabolites and Clinical Outcomes in Extremely Premature Infants.

Miguel Guardado, Dara Torgerson, Cheryl Chapin, Azuka Atum, Ryan D Hernandez, Ronald Clyman, Rebecca Simmons, Samuel Parry, Philip L Ballard

Abstract readMulticenter StudyMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miguel GuardadoDepartment of Biological and Medical Informatics, University of California, San Francisco, San Francisco, California.
Dara TorgersonDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Cheryl ChapinDepartment of Pediatrics, University of California, San Francisco, San Francisco, California.
Azuka AtumDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Ryan D HernandezDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California.
Ronald ClymanDepartment of Pediatrics, University of California, San Francisco, San Francisco, California.
Rebecca SimmonsDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Samuel ParryDepartment of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Philip L BallardDepartment of Pediatrics, University of California, San Francisco, San Francisco, California.

Funding

Rarely Common: Uncovering the dominant role of rare variants in the genetic architecture of complex human traits.R01GM142112 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2021 to 2024
$2.2M
Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infantsR01HL153429 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALLARD, PHILIP L., TORGERSON, DARA · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL153429NIGMS NIH HHS R01 GM142112NIH grants R01HL153429NIH grants RO1GM142112
6 · The paper itself

Abstract

Extremely premature infants are treated with acetaminophen (APAP) for pain and patent ductus arteriosus. High doses of APAP in adults are toxic, and a recent study found an association between APAP metabolite levels in mothers' breast milk and both bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in their premature infants. In this study, we determined levels of APAP metabolites in the urine of infants at high risk for BPD and ROP.Biorepository urine samples from 314 infants <29 weeks' gestation in the multicenter TOLSURF and PROP studies were analyzed by untargeted UHPLC:MS/MS (Metabolon, Inc.). We performed multivariate logistic regression and meta-analysis to examine associations between APAP metabolite levels and clinical outcomes.4-APAP sulfate was the most abundant of eight detected APAP metabolites and was present in 95% of urines. There were high correlations between levels of 4-APAP sulfate and the other APAP metabolites. In longitudinal studies on a subgroup of infants (day 6-56), periods of elevated 4-APAP sulfate occurred in 24/28 infants and were of longer duration (10.5 vs. 4.2 days,

Indexed as

AcetaminophenAnalgesics, Non-NarcoticBronchopulmonary DysplasiaInfant, Extremely PrematureRetinopathy of PrematurityDuctus Arteriosus, PatentFemaleGestational AgeHumansInfant, NewbornLogistic ModelsMaleMultivariate AnalysisTandem Mass SpectrometryAcetaminophenAnalgesics, Non-Narcotic

Identifiers

PMID39788537
PMCPMC12360863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.