Evidence map›Paper›PMID 39788532›Full record

ArticleEuropean journal of dentistry2025

Moringa oleifera L. Nanosuspension Extract Administration Affects Heat Shock Protein-10 and -70 under Orthodontics Mechanical Force In Vivo.

Ari Triwardhani, Alida Alida, Ervina Restiwulan Winoto, Adya Pramusita, Nurul Aisyah Rizki Putranti, Kristian Satrio Ariadi, Okso Brillian Pribadi, Amelia Aisyiah Anwar, Alqomariyah Eka Purnamasari, Rifqah Ananda Mappananrang and 5 more

Abstract read
In one paragraph

Article in European journal of dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ari TriwardhaniDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Alida AlidaDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ervina Restiwulan WinotoDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Adya PramusitaDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nurul Aisyah Rizki PutrantiDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Kristian Satrio AriadiDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Okso Brillian PribadiDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Amelia Aisyiah AnwarFaculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Alqomariyah Eka PurnamasariFaculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Rifqah Ananda MappananrangFaculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Putri Cahaya SitumorangDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia.
Wibi RiawanDepartment of Molecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia.ORCID 0000-0001-5027-5051
Tengku Natasha Eleena Binti Tengku Ahmad NoorMembership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom.
Albertus Putera NugrahaFaculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.ORCID 0009-0008-5455-3387
Alexander Patera NugrahaDepartment of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe mechanical stimulation known as orthodontic mechanical force (OMF) causes biological reactions in orthodontic tooth movement (OTM). Heat shock protein-70 (HSP-70) needs pro-inflammatory cytokines to trigger bone resorption in OTM; nevertheless, heat shock protein-10 (HSP-10), a "Alarmin" cytokine, should control these pro-inflammatory cytokines to get the best alveolar bone remodeling (ABR). MATERIAL AND

methodsA total of 36 Wistar rats (

resultsIn both the OMF and MONE groups, HSP-70 peaked on day 14 and began to fall on day 21. HSP-10 peaked on day 21, but along with MONE, it also began to progressively decline on days 14 and 21, with significant differences (

conclusionAccording to immunohistochemistry evidence, postadministration of MONE markedly elevated HSP-10 but lowered HSP-70 expression in the alveolar bone of Wistar rats under OMF.

Identifiers

PMID39788532
PMCPMC12020578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.