Evidence map›Paper›PMID 39788473›Full record

ArticleBiochimica et biophysica acta. Biomembranes2025

Differential effects of endo- and exopolyphosphatase expression on the induction of the mitochondrial permeability transition pore.

Yaw Akosah, Vedangi Hambardikar, Maria Neginskaya, Sally Morris, Maria E Solesio, Evgeny V Pavlov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaw AkosahDepartment of Molecular Pathobiology, New York University, New York, NY, USA.
Vedangi HambardikarDepartment of Biology, Rutgers University, Camden, NJ, USA.
Maria NeginskayaDepartment of Molecular Pathobiology, New York University, New York, NY, USA.
Sally MorrisDepartment of Molecular Pathobiology, New York University, New York, NY, USA.
Maria E SolesioDepartment of Biology, Rutgers University, Camden, NJ, USA.
Evgeny V PavlovDepartment of Molecular Pathobiology, New York University, New York, NY, USA. Electronic address: ep37@nyu.edu.

Funding

Molecular mechanisms of the mitochondrial permeability transitionR35GM139615 · NIGMS · NEW YORK UNIVERSITY · PI PAVLOV, EVGENY · 2021 to 2025
$2.3M
Mitochondrial inorganic polyphosphate in the mammalian stress response.R35GM150799 · NIGMS · RUTGERS THE STATE UNIV OF NJ CAMDEN · PI Maria de la Encarnacion Solesio Torregrosa · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM139615NIGMS NIH HHS R35 GM150799
6 · The paper itself

Abstract

Inorganic polyphosphate (polyP) is a polymer that consists of a series of orthophosphates connected by high-energy phosphoanhydride bonds, like those found in ATP. In mammalian mitochondria, polyP has been linked to the activation of the mitochondrial permeability transition pore (mPTP). However, the details of this process are not completely understood. The activation of mPTP by polyP may involve the regulation of bioenergetics, Ca

Indexed as

Acid Anhydride HydrolasesMitochondriaMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreCalciumCell Line, TumorHumansPolyphosphatesAcid Anhydride HydrolasesCalciumexopolyphosphataseMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePolyphosphatesHolographic imagingMitochondriaPermeability transitionPolyphosphate

Identifiers

PMID39788473
PMCPMC12414328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.