Evidence map›Paper›PMID 39788297›Full record

ArticleThe American journal of clinical nutrition2025

Determinants of maternal and infant omega-3 status at 3 months postpartum: findings from the APrON longitudinal cohort study.

Jaqueline Munhoz, Nour Wattar, Susan Goruk, Mohammadreza Pakseresht, Megan Jarman, Laura Forbes, Rhonda C Bell, Fatheema B Subhan, Catherine J Field

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Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jaqueline MunhozDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Nour WattarDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Susan GorukDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Mohammadreza PaksereshtDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Megan JarmanInstitute of Health and Neurodevelopment, School of Psychology, College of Health and Life Sciences, Aston University. Birmingham, UK.
Laura ForbesDepartment of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, Canada.
Rhonda C BellDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Fatheema B SubhanDepartment of Nutrition and Food Science, California State Polytechnic University, Pomona, CA, USA.
Catherine J FieldDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. Electronic address: cjfield@ualberta.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOmega-3 long-chain-polyunsaturated fatty acids (LCPUFAs) are important dietary components for maternal and infant health during pregnancy and lactation.

objectivesThis study investigated determinants of maternal and infant LCPUFAs status at 3 mo postpartum and the relationship between maternal serum, maternal milk, and infant LCPUFAs.

methodsThis cross-sectional study included mothers (n = 1481) and their offspring (n = 526) at 3 mo postpartum from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort. Maternal dietary intake (24-h recall), blood samples from mothers and infants, and maternal milk were collected. Fatty acid composition (relative % of total fatty acids) was determined by gas-liquid chromatography. Linear regression analyses explored associations between diet, sociodemographic factors, and fatty acid status.

resultsIn a multivariable-adjusted analysis, maternal total dietary intake (supplement + food) was positively associated with the percentage of DHA (standardized ß [Sβ] = 0.158; ß = 0.394; 95% [confidence interval] CI: 0.192, 0.558; P < 0.001) in maternal serum phospholipids. Similar associations were found for DHA and eicosapentaenoic acid in maternal milk and plasma phospholipids of infants. Prepregnancy body mass index (BMI) was negatively associated with DHA (Sß = -0.073; ß = -0.003; 95% CI: -0.006, -0.001; P = 0.008) and positively associated with total saturated fatty acids (Sß = 0.086; ß = 0.111; 95% CI: 0.042, 0.180; P = 0.002) in maternal milk. Infants receiving formula combination with maternal milk had lower percentage of DHA (Sß = -0.177; ß = -0.390; 95% CI: -0.604, -0.175; P < 0.001) and arachidonic acid (Sß = -0.106; ß = -0.595; 95% CI: -1.122, -0.067; P = 0.027) in their plasma phospholipids compared with those who fed exclusively maternal milk.

conclusionsMaternal total dietary intake and prepregnancy BMI are independently associated with their serum fatty acid status during lactation, whereas maternal diet, milk fatty acid composition, and lactation status are important determinants of infant n-3 LCPUFAs fatty acid status. Future research should investigate the impact of these differences in fatty acid status on infant health outcomes.

Indexed as

Fatty Acids, Omega-3Maternal Nutritional Physiological PhenomenaMilk, HumanNutritional StatusPostpartum PeriodAdultAlbertaCohort StudiesCross-Sectional StudiesDietDocosahexaenoic AcidsFemaleHumansInfantInfant, NewbornLongitudinal StudiesDocosahexaenoic AcidsFatty Acids, Omega-3dietary intakedocosahexaenoic acidfatty acidshuman milklactation

Identifiers

PMID39788297
PMCPMC11923373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.