Evidence map›Paper›PMID 39788155›Full record

ArticleNature2025

Repurposing of a gill gene regulatory program for outer-ear evolution.

Mathi Thiruppathy, Lauren Teubner, Ryan R Roberts, Micaela C Lasser, Alessandra Moscatello, Ya-Wen Chen, Christian Hochstim, Seth Ruffins, Arijita Sarkar, Jade Tassey and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Pathogenic variants inGenes & diseases · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mathi ThiruppathyDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6337-3256
Lauren TeubnerDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ryan R RobertsDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Micaela C LasserDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Alessandra MoscatelloSchool of Medicine, New York Medical College, Valhalla, NY, USA.
Ya-Wen ChenDepartment of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2382-8444
Christian HochstimDivision of Otolaryngology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Seth RuffinsDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Arijita SarkarDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jade TasseyDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Denis EvseenkoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Thomas P LozitoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Helen Rankin WillseyDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8404-3291
J Andrew GillisJosephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA, USA.
J Gage CrumpDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. gcrump@usc.edu.ORCID 0000-0002-3209-0026

Funding

Progenitor Regulation in Craniofacial Development and RegenerationR35DE027550 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRUMP, GAGE D · 2017 to 2024
$8.0M
Why Don’t Lizards Regenerate Perfect Tails Like Salamanders?R01GM115444 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LOZITO, THOMAS PETER · 2016 to 2025
$3.3M
Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
Investigating the emergence of vertebrate cranial cartilage diversityF31DE030706 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THIRUPPATHY, MATHI · 2021 to 2023
$143k
NICHD NIH HHS T32 HD060549NIDCR NIH HHS F31 DE030706NIDCR NIH HHS R35 DE027550NIGMS NIH HHS R01 GM115444
6 · The paper itself

Abstract

How new structures emerge during evolution has long fascinated biologists. An example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones

Indexed as

Biological EvolutionEarGene Expression Regulation, DevelopmentalGillsAnimalsCartilageEnhancer Elements, GeneticHomeodomain ProteinsHumansTranscription FactorsZebrafishDistal-less homeobox proteinsHomeodomain ProteinsTranscription Factors

Identifiers

PMID39788155
PMCPMC12989155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.