ArticleCell metabolism2025
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Resistance-based training improves mitochondrial capacity and redox balance in aging adults, independent of polyphenol supplementation.Redox biology · 2026Trial
- Mitotic assembly of respiratory supercomplexes ensures accurate cell division and fuels tumor growth.EMBO reports · 2026Article
- Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective.Science advances · 2026Article
- Functional Reconstitution of Mitochondrial Respiratory Supercomplexes.Journal of visualized experiments : JoVE · 2026Article
- Hypertensive mt. tRNARedox biology · 2026Article
- Higher-order structural organization of mitochondrial metabolism.The Journal of biological chemistry · 2026Review
- TACO1 regulates mitochondrial adaptation in hypertension-induced cardiac remodeling and heart failure.Research square · 2026Article
- Mitochondrial respirasome-like supercomplexes support metabolic flexibility in yeast.Nature communications · 2026Article
- Metabolic dysfunction-associated steatotic liver disease: On track to become the dominant etiology of hepatocellular carcinoma: Reply to correspondence on "Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation".Clinical and molecular hepatology · 2026Article
- Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane.Nature communications · 2026Article
- Aging-related gene signatures as potential biomarkers in ischemic stroke: an integrated bioinformatics and machine learning study.BMC neurology · 2026Article
- Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts.Antioxidants (Basel, Switzerland) · 2026Article
- Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies.Frontiers in pharmacology · 2026Review
- The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan.Nature aging · 2025Article
- Mammalian mitohormesis: from mitochondrial stressors to organismal benefits.The EMBO journal · 2025Review
- Supercomplex Restructuring in Heart Mitochondria of COX7A1-Deficient Mice.Biomolecules · 2025Article
- Respiratory complex IIIbioRxiv : the preprint server for biology · 2025Article
- Mitochondrial dysfunction as a therapeutic nexus in HFpEF: therapeutic target and pharmacological advances.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Chao LiangCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
Abhilash PadavannilDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Shan ZhangCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
Sheryl BehCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
David R L RobinsonDepartment of Biochemistry and Pharmacology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia.
Jana MeisterknechtFunctional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Alfredo Cabrera-OreficeFunctional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Timothy R KovesDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Chika WatanabeDepartment of Pediatrics, Jichi Medical School, Shimotsuke-shi, Tochigi, Japan.
Miyuki WatanabeDepartment of Pediatrics, Jichi Medical School, Shimotsuke-shi, Tochigi, Japan.
María IllescasInstituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Radiance LimCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
Jordan M JohnsonDiabetes and Metabolism Research Center, The University of Utah, Salt Lake City, UT, USA.
Shuxun RenCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore.
Ya-Jun WuDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Dennis KappeiCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Anna Maria GhelliDipartimento di Farmacia e Biotecnologie (FABIT), Università di Bologna, 40126 Bologna, Italy.
Katsuhiko FunaiDiabetes and Metabolism Research Center, The University of Utah, Salt Lake City, UT, USA.
Hitoshi OsakaDepartment of Pediatrics, Jichi Medical School, Shimotsuke-shi, Tochigi, Japan.
Deborah MuoioDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Cristina UgaldeInstituto de Investigación Hospital 12 de Octubre, Madrid, Spain; Center for Biological Research Margarita Salas (CIB-CSIC), Madrid, Spain; CIBER de Enfermedades Raras, U723, Madrid, Spain.
Ilka WittigFunctional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
David A StroudDepartment of Biochemistry and Pharmacology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC, Australia; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
James A LettsDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Lena HoCardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore. Electronic address: lena@ho-lab.org.
Funding
PE methylation in skeletal muscle energy efficiencyR01DK107397 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2017 to 2025
$3.8MLOOH-induced muscle atrophy with ageR01AG074535 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Micah J Drummond, Katsuhiko Funai · 2022 to 2026
$3.0MUnderstanding the Mechanisms of Respiratory Supercomplexes and mitochondrial Complex IR35GM137929 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LETTS, JAMES ANTHONY · 2020 to 2025
$2.3MLands cycle and skeletal muscle insulin actionR01DK127979 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2022 to 2025
$1.9MPE In Modulation of Energy Flux Through OxphosR01GM144613 · NIGMS · UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2021 to 2024
$1.6MNIA NIH HHS R01 AG074535NIDDK NIH HHS R01 DK107397NIDDK NIH HHS R01 DK127979NIGMS NIH HHS R01 GM144613NIGMS NIH HHS R35 GM137929
Abstract
Mitochondrial electron transport chain (ETC) complexes partition between free complexes and quaternary assemblies known as supercomplexes (SCs). However, the physiological requirement for SCs and the mechanisms regulating their formation remain controversial. Here, we show that genetic perturbations in mammalian ETC complex III (CIII) biogenesis stimulate the formation of a specialized extra-large SC (SC-XL) with a structure of I
Indexed as
Electron Transport Complex IIIAnimalsCryoelectron MicroscopyElectron TransportHumansMiceMice, Inbred C57BLMitochondriaOxidation-ReductionReactive Oxygen SpeciesElectron Transport Complex IIIReactive Oxygen Speciescomplex Icomplex IIIcomplex III ROScryo-EM structureelectron transport chainischemia reperfusion injurymitohormesisrespirasomereverse electron transportsupercomplex
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.