ReviewNeuron2025
Biological sex matters in brain aging.
Abstract readReview
In one paragraph
Review in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Women.Stroke (Hoboken, N.J.) · 2026Article
- Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.Physiology (Bethesda, Md.) · 2026Review
- Shared Risk Genes and Casual Relationships across Sex Hormone Related Traits and Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Lifelong behavioral screen reveals an architecture of vertebrate aging.Science (New York, N.Y.) · 2026Article
- Sex-dependent dopaminergic vulnerability may contribute to sex differences in Parkinson's disease risk.Brain communications · 2026Article
- A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study.Advanced biology · 2025Article
- Life-long behavioral screen reveals an architecture of vertebrate aging.bioRxiv : the preprint server for biology · 2025Article
- Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Single-cell, multi-region profiling of the macaque brain across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Females.medRxiv : the preprint server for health sciences · 2025Article
- Sex differences in healthy brain aging are unlikely to explain higher Alzheimer's disease prevalence in women.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aging activates escape of the silent X chromosome in the female mouse hippocampus.Science advances · 2025Article
- Changes in voxel-wise gray matter asymmetry over time.Frontiers in neuroscience · 2025Article
- Sex and ethnicity in early-onset Alzheimer's disease biomarkers and global function.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Disparities in women's health and clinical considerations from a translational science perspective: A narrative review and framework for future directions.Women's health (London, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Dena B DubalDepartment of Neurology and Weill Institute for Neurosciences, University of California San Franciso, San Francisco, CA, USA; Bakar Aging Research Institute, University of California San Franciso, San Francisco, CA, USA. Electronic address: dena.dubal@ucsf.edu.
Coleen T MurphyLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. Electronic address: ctmurphy@princeton.edu.
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: ys3214@cumc.columbia.edu.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Molecular and Computational Biology Department, USC Dornsife College of Letters, Arts and Sciences, Los Angeles, CA, USA; Biochemistry and Molecular Medicine Department, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA; USC Stem Cell Initiative, Los Angeles, CA, USA. Electronic address: bbenayou@usc.edu.
Funding
THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5MData Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHATNANI, HEMALI · 2021 to 2025
$13.1MCombinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's DiseaseR01AG057706 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGE, FRED H, GLASS, CHRISTOPHER K · 2017 to 2021
$8.1MEnhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskR01DK127778 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EGLI, DIETER MEINRAD, ROSENFELD, MICHAEL G · 2020 to 2023
$4.5MToward the Tissue-ome: A Map of the C. elegans Cell-specific TranscriptomeDP1GM119167 · NIGMS · PRINCETON UNIVERSITY · PI MURPHY, COLEEN TARA · 2015 to 2019
$4.0MSystems Modeling of Alzheimers Disease in C. elegansRF1AG057341 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MURPHY, COLEEN TARA, SUH, YOUSIN · 2017 to 2017
$3.7MNew Methods to Uncover Global Transcriptional Programs for Disease Risk VariantsR01GM104459 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SUH, YOUSIN · 2013 to 2016
$2.5MMechanisms of X-Chromosome-dependent Sex Difference inAlzheimers DiseaseRF1AG068325 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2020 to 2020
$2.3MUnderstanding the regulation and impact of transposable elements in Vertebrate health and diseaseR35GM142395 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2021 to 2025
$2.2MFrom in vivo to in vitro heterochronic parabiosis to identify geronic factorsR01AG057433 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RANDO, THOMAS A., SUH, YOUSIN · 2017 to 2020
$2.1MDeciphering hormonal regulation of neutrophil biologyR01AG076433 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2022 to 2025
$2.1MNIA NIH HHS P01 AG017242NIA NIH HHS R01 AG057433NIA NIH HHS R01 AG057706NIA NIH HHS R01 AG061521NIA NIH HHS R01 AG068325NIA NIH HHS R01 AG069750NIA NIH HHS R01 AG076433NIA NIH HHS R01 AG079176NIA NIH HHS RF1 AG057341NIA NIH HHS RF1 AG068325NIA NIH HHS RF1 AG079176NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG076040NIDDK NIH HHS R01 DK127778NIGMS NIH HHS DP1 GM119167NIGMS NIH HHS R01 GM104459NIGMS NIH HHS R35 GM142395
Abstract
Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance for human health. Unraveling and harnessing mechanistic etiologies of sex differences may reveal new diagnostics and therapeutics for the aging brain.
Indexed as
AgingBrainSex CharacteristicsAnimalsFemaleHumansMale
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.