Trial reportThe journal of nutrition, health & aging2025
Estimating protein intake in sarcopenic older adults: combining food diaries and weighed powders versus 24-hour urine collections.
Trial report in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03649698 (Exercise and Nutrition for Healthy AgeiNg), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Exercise and Nutrition for Healthy AgeiNg: Anabolic Interventions for Older People With (Pre)Sarcopenia to Improve Physical Functioning, Muscle Mass and Muscle Strength and to Understand the Underlying Mechanisms of Action.
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9 authors.
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Abstract
objectivesAdequate protein intake and protein supplementation has a beneficial role in the prevention and treatment of sarcopenia. The achievement and quantification of the recommended total protein intake by sarcopenic older adults receiving protein supplementation has not been studied. The aim of this study was to compare the accuracy of protein intake estimated from a combination of four-day food diaries and weighed protein powders against total protein intake estimated from 24-h urine samples.
designLongitudinal data analysis of the ongoing Exercise and Nutrition for Healthy AgeiNg (ENHANce) study. SETTING AND
participantsThis study included community-dwelling older adults aged ≥65 years) diagnosed with sarcopenia (EWGSOP2-criteria). MEASUREMENTS: The amount of protein/placebo supplement was individualized to achieve a mean total protein intake of 1.5 g/kg BW/day. Total protein intake in participants was determined by a combination of weighed protein powders and four-day food diaries and by nitrogen-excretion in 24-h urine samples at eight different timepoints during the intervention. Mean differences and Lin's concordance correlation coefficients were used to assess agreement between the two methods.
resultsAfter 12 weeks, nitrogen analysis showed that the mean total protein intake was 1.31 g/kg BW in the protein powder group (n = 33) and 0.86 g/kg BW in the placebo group (n = 17). Mean protein intake according to the combination of food diaries and weighed powders (87.0 g/day) was overestimated by 7.7 g/day compared to the method using 24-h urine samples (79.3 g/day). Correlation between protein intake derived from the combined method and 24-h urine samples varied between 0.244-0.565 and 0.382-0.641 in the placebo group and protein group, respectively.
conclusionBoth the 24-h urine samples and combined food diaries with weighed protein powders demonstrated that protein supplementation increased protein intake to meet the daily recommended amount of protein intake for older adults (1.0-1.2 g/kg BW), but not that for sarcopenic older adults (1.5 g/kg BW). While a fair to moderately strong correlation was observed between the methods, there was significant variability in the protein intake estimates. Additional research is needed to assess the accuracy of other potential techniques in determining protein intake in an older population. The ENHANce study was registered on ClinicalTrails.gov (NCT03649698).
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