Evidence map›Paper›PMID 39787630›Full record

ArticleInfant behavior & development2025

The utility of multiple assessments in infancy and toddlerhood to predict middle childhood ADHD symptoms: Temperamental, behavioral, and genetic contributions.

Lindsay C Chromik, Lauren M Friedman, Gabrielle Fabrikant-Abzug, Mary C Davis, Leah D Doane, Kathryn Lemery-Chalfant

Abstract readTwin Study
In one paragraph

Article in Infant behavior & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsay C ChromikDepartment of Psychology, Arizona State University, USA. Electronic address: lchromik@asu.edu.
Lauren M FriedmanDepartment of Psychology, Arizona State University, USA.
Gabrielle Fabrikant-AbzugDepartment of Psychology, Arizona State University, USA.
Mary C DavisDepartment of Psychology, Arizona State University, USA.
Leah D DoaneDepartment of Psychology, Arizona State University, USA.
Kathryn Lemery-ChalfantDepartment of Psychology, Arizona State University, USA.

Funding

Genetic and Environmental Origins of the Development of Pain in ChildrenR01HD086085 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Mary Colleen Davis, Kathryn Lemery-Chalfant · 2016 to 2026
$6.0M
Social and Genetic Contributions to Children's Sleep, Health, and FunctioningR01HD079520 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI DOANE SAMPEY, LEAH DARRAH, LEMERY-CHALFANT, KATHRYN · 2015 to 2025
$6.0M
Enhancing behavioral parent training for parents and children affected by ADHDK23MH128536 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Lauren Melissa Friedman · 2024 to 2026
$569k
NICHD NIH HHS R01 HD079520NICHD NIH HHS R01 HD086085NIMH NIH HHS K23 MH128536
6 · The paper itself

Abstract

backgroundEarly intervention is effective for reducing ADHD symptoms and related impairments, yet methods of identifying young children in need of services are lacking. Most early predictors of ADHD previously identified are of limited clinical utility. This study examines several theoretically relevant predictors of ADHD in infancy and toddlerhood and whether assessment at multiple time points improves prediction. We also examine whether links between early risk factors and middle childhood ADHD are driven by shared genetic and/or environmental mechanisms to identify potential early intervention targets.

method614 twins (52.12 % female, 58.50 % non-Hispanic White) participated in a larger study on genetic and environmental contributions to mental health outcomes. Caregiver-reported attention and behavior problems in infancy (M = 12.67 months) and toddlerhood (M = 32.18 months) and caregiver-reported temperament (attentional focusing, impulsivity, inhibitory control) in toddlerhood were used to predict caregiver-reported ADHD symptoms in middle childhood (M = 8.78 years).

resultsOnly behavior problems in infancy and toddlerhood were robust predictors of caregiver-reported ADHD symptoms in middle childhood. Using multiple timepoints did not improve predictive ability. The relationship between infant behavior problems and caregiver reported middle childhood ADHD symptoms was explained by both environmental and genetic influences, whereas environmental influences almost entirely explained the relationship between toddler behavior problems and caregiver-reported middle childhood ADHD symptoms. IMPLICATIONS: Behavior problems in toddlerhood showed the strongest predictive utility, and links to later ADHD were largely driven by environmental factors, suggesting that psychosocial interventions modifying the child's environment may be particularly effective for reducing ADHD risk.

Indexed as

Attention Deficit Disorder with HyperactivityChild BehaviorTemperamentChildChild, PreschoolFemaleHumansInfantMaleRisk FactorsADHDEarly risk factorsGenetic influencesInfancyLongitudinalToddlerhoodTwin design

Identifiers

PMID39787630
PMCPMC11892346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.