ArticleNoise & health
Inflammatory Biomarkers and Tinnitus in Older Adults.
Article in Noise & health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Pulsed Radiofrequency of the Stellate Ganglion for Tinnitus: A Two-Case Series Suggesting a Novel Approach.Case reports in anesthesiology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTinnitus refers to a common disorder affecting older adults frequently. This condition can disturb mental health and psychological well-being and contribute to cognitive decline. Despite recent advances in research, its pathophysiology remains incompletely understood. Therefore, this study aimed to investigate the sensation of tinnitus, its consequences on the quality of life of older adults, and its correlation with cytokine levels. METHODS AND MATERIAL: This cross-sectional study included a sample of 103 independent older adults. Information regarding clinical history, tinnitus, and hearing loss was obtained through interviews. Assessment of tinnitus intensity and resulting impairments was conducted using Visual Analogue Scale (VAS) and Tinnitus Handicap Index (THI), respectively. Subjects underwent audiological evaluation and were measured for inflammatory markers. Statistical analyses included chi-square, Mann-Whitney, and Kruskal-Wallis tests and calculation of the effect size (Φ).
resultsThe condition of older adults with tinnitus (51.5%) was associated with hearing loss and previous noise exposure. No differences were observed in the cytokines between groups with and without tinnitus (P > 0.05), whereas a difference was found in the interleukin-10 (IL-10) of the male group (P = 0.016; r = 0.69). In those with tinnitus, VAS had a median and (interquartile range) of 5 (2-7), and the values were 21 (10-38) for THI. In addition, VAS and minimum masking level exhibited a significant correlation with IL-6 (P = 0.018; rs = 0.335) and IL-2 (P = 0.035; rs = 0.299), respectively. Furthermore, the groups with intense and mild VAS presented different levels of tumour necrosis factor alpha (TNF-α) (P = 0.041; E2R = 0.12).
conclusionThe results reveal an association between tinnitus and hearing loss and previous noise exposure. Moreover, increased sound-masking levels and VAS correlated with IL-2 and IL-6, respectively. TNF-α levels varied between the mild and intense VAS groups.
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