ArticleCell reports2025
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Dopamine dynamics in human anterior cingulate cortex during Pavlovian-instrumental conflict.bioRxiv : the preprint server for biology · 2026Article
- Octopamine and tyramine dynamics predict learning rate phenotypes during associative conditioning in honey bees.Science advances · 2026Article
- Thickness Is More Than Affective Valence: Evaluative Language Through the Lenses of Psycholinguistics.Cognitive science · 2026Article
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- Progress toward Multianalyte Neurochemical Detection: Techniques and Applications.ACS chemical neuroscience · 2025Review
- Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson's disease patients.Nature communications · 2025Article
- Stabilized carbon coating on microelectrodes for scalable and interoperable neurotransmitter sensing.Nature communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Funding
Abstract
Words represent a uniquely human information channel-humans use words to express thoughts and feelings and to assign emotional valence to experience. Work from model organisms suggests that valence assignments are carried out in part by the neuromodulators dopamine, serotonin, and norepinephrine. Here, we ask whether valence signaling by these neuromodulators extends to word semantics in humans by measuring sub-second neuromodulator dynamics in the thalamus (N = 13) and anterior cingulate cortex (N = 6) of individuals evaluating positive, negative, and neutrally valenced words. Our combined results suggest that valenced words modulate neuromodulator release in both the thalamus and cortex, but with region- and valence-specific response patterns, as well as hemispheric dependence for dopamine release in the anterior cingulate. Overall, these experiments provide evidence that neuromodulator-dependent valence signaling extends to word semantics in humans, but not in a simple one-valence-per-transmitter fashion.
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Registered trials
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