Evidence map›Paper›PMID 39786992›Full record

ArticleCell reports2025

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior.

Victoria L Corbit, Sean C Piantadosi, Jesse Wood, Srividhya S Madireddy, Clare J Y Choi, Ilana B Witten, Aryn H Gittis, Susanne E Ahmari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Striatal ensemble activity in an innate naturalistic behavior.bioRxiv : the preprint server for biology · 2023
    Article
  3. Article
  4. The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victoria L CorbitCenter for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sean C PiantadosiCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Jesse WoodTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Srividhya S MadireddyCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Clare J Y ChoiPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ilana B WittenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Aryn H GittisCenter for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Susanne E AhmariCenter for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: ahmarise@upmc.edu.

Funding

Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s DiseaseR35NS132213 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI Aryn Hilary Gittis · 2023 to 2026
$2.8M
Testing the Role of Circuit Plasticity in the Pathology and Treatment of AbnormalR01MH104255 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AHMARI, SUSANNE ELIZABETH · 2014 to 2018
$2.3M
Dissecting the role of striatal cell types in abnormal repetitive behaviors and treatment responseR01MH119837 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AHMARI, SUSANNE ELIZABETH · 2019 to 2022
$1.9M
Investigating the role of anterior lateral motor cortex in control and execution of sequenced behaviorsR01NS125141 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Susanne Elizabeth Ahmari · 2022 to 2026
$1.7M
Organization and Function of Striatal Microcircuits in Health and DiseaseR00NS076524 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI GITTIS, ARYN HILARY · 2013 to 2015
$736k
Investigating the microcircuit role of striatal fast-spiking interneurons in Obsessive-Compulsive disorderF31MH110125 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CORBIT, VICTORIA L · 2017 to 2019
$133k
NIMH NIH HHS F31 MH110125NIMH NIH HHS R01 MH104255NIMH NIH HHS R01 MH119837NINDS NIH HHS R00 NS076524NINDS NIH HHS R01 NS125141NINDS NIH HHS R35 NS132213
6 · The paper itself

Abstract

Understanding how corticostriatal circuits mediate behavioral selection and initiation in a naturalistic setting is critical to understanding behavior choice and execution in unconstrained situations. The central striatum (CS) is well poised to play an important role in these spontaneous processes. Using fiber photometry and optogenetics, we identify a role for CS in grooming initiation. However, CS-evoked movements resemble short grooming fragments, suggesting additional input is required to appropriately sustain behavior once initiated. Consistent with this idea, the anterior lateral motor area (ALM) demonstrates a slow ramp in activity that peaks at grooming termination, supporting a potential role for ALM in encoding grooming bout length. Furthermore, optogenetic stimulation of ALM-CS terminals generates sustained grooming responses. Finally, dual-region photometry indicates that CS activation precedes ALM during grooming. Taken together, these data support a model in which CS is involved in grooming initiation, while ALM may encode grooming bout length.

Indexed as

Behavior, AnimalCorpus StriatumGroomingMotor CortexAnimalsMaleMiceOptogeneticsanterior lateral motor areacalcium imagingCP: Neurosciencegroomingoptogeneticsphotometryramping activitySLEAPspontaneous behaviorstriatum

Identifiers

PMID39786992
PMCPMC11963507

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.