Evidence map›Paper›PMID 39786930›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Nonapoptotic role of EGL-1 in exopher production and neuronal health in

Zheng Wu, Eric A Cardona, Jesse A Cohn, Jonathan T Pierce

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zheng WuDepartment of Neuroscience, Center for Learning and Memory, Waggoner Center for Alcohol & Addiction Research, University of Texas at Austin, Austin, TX 78712.
Eric A CardonaDepartment of Neuroscience, Center for Learning and Memory, Waggoner Center for Alcohol & Addiction Research, University of Texas at Austin, Austin, TX 78712.
Jesse A CohnDepartment of Neuroscience, Center for Learning and Memory, Waggoner Center for Alcohol & Addiction Research, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-0433-6321
Jonathan T PierceDepartment of Neuroscience, Center for Learning and Memory, Waggoner Center for Alcohol & Addiction Research, University of Texas at Austin, Austin, TX 78712.

Funding

Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticityR35GM122463 · NIGMS · BRANDEIS UNIVERSITY · PI Piali Sengupta · 2017 to 2026
$7.7M
Synergistic patterned neurodegeneration by APP and APOE4RF1AG057355 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2017 to 2017
$1.9M
Systematic functional study of 21st chromosome ortholog overexpression in C. elegansR21OD032463 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2022 to 2023
$574k
HHS | National Institutes of Health (NIH) RF1AG057355HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R21OD032463HHS | NIH | National Institute of Mental Health (NIMH) R01 GM122463NIA NIH HHS RF1 AG057355NIGMS NIH HHS R35 GM122463NIH HHS R21 OD032463
6 · The paper itself

Abstract

While traditionally studied for their proapoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondrial dynamics regulation. Here, we find that EGL-1, the BH3-only protein in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNeuronsAnimalsApoptosisDendritesExocytosisMitochondriaMitochondrial DynamicsRepressor ProteinsCaenorhabditis elegans ProteinsEGL-1 protein, C elegansRepressor ProteinsBH3-only proteinexophermitochondrianeuroprotection

Identifiers

PMID39786930
PMCPMC11745333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.