Evidence map›Paper›PMID 39786704›Full record

SynthesisInternational urology and nephrology2025

Exploring the link between sex hormone-binding globulin levels and prostate cancer risk: a comprehensive systematic review and meta-analysis.

Prakasini Satapathy, Shilpa Gaidhane, Ashok Kumar Bishoyi, Subbulakshmi Ganesan, Karthikeyan Jayabalan, Swati Mishra, Manpreet Kaur, Ganesh Bushi, Muhammed Shabil, Rukshar Syed and 8 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Prakasini Satapathy *Centre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, 140417, India.
Shilpa Gaidhane *One Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.
Ashok Kumar BishoyiMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, Gujarat, 360003, India.
Subbulakshmi GanesanDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Karthikeyan JayabalanDepartment of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Swati MishraDepartment of Pharmacology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751003, India.
Manpreet KaurDepartment of Pharmacy, Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, 140307, India.
Ganesh BushiSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Muhammed ShabilUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India. mohdshabil99@gmail.com.
Rukshar SyedIES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, 462044, India.
Sonam PuriNew Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India.
Sunil KumarDepartment of Microbiology, Graphic Era (Deemed to Be University), Clement Town, Dehradun, 248002, India.
Sabah AnsarDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, 11433, Riyadh, Saudi Arabia.
Sanjit SahDepartment of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, 411018, India.
Diptismita JenaCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Zaid KhanNoida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India.
Quazi Syed ZahiruddinSouth Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India. zahirquazi@dmiher.edu.in.
Khang Wen GohFaculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex hormone-binding globulin (SHBG) plays a critical role in regulating androgen bioavailability and has been hypothesized to influence prostate cancer risk, though existing evidence is inconsistent. This systematic review and meta-analysis aimed to evaluate the association between SHBG levels and prostate cancer risk.

methodsA comprehensive search was conducted across PubMed, Embase, and Web of Science for studies published up to December 1, 2024. Observational studies assessing SHBG levels and prostate cancer risk were included. Effect sizes were pooled using random-effects meta-analysis. Heterogeneity was evaluated using the I

resultsSixteen studies, including 720,298 participants and 90,799 prostate cancer cases, were analyzed. The pooled odds ratio (OR) for prostate cancer risk per unit increase in SHBG was 0.907 (95% CI 0.799-1.030), indicating no statistically significant association. Substantial heterogeneity was observed among the included studies (I

conclusionThis meta-analysis showed a complex relationship between SHBG levels and prostate cancer risk. While overall findings do not support a statistically significant association, higher SHBG levels may confer a protective role in specific contexts. Further research is needed to elucidate mechanisms, reduce heterogeneity, and validate SHBG as a biomarker for risk stratification.

Indexed as

Prostatic NeoplasmsSex Hormone-Binding GlobulinHumansMaleRisk AssessmentRisk FactorsSex Hormone-Binding GlobulinSHBG protein, humanAndrogen regulationMeta-analysisProstate cancerSex hormone-binding globulinSystematic review

Identifiers

PMID39786704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.