ArticleJournal of fluorescence2025
A Pyrene-Derived Fluorescent Probe for the Visual Detection of Protamine and Trypsin Activity.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
A pyrene-derived fluorescent probe (P4CG) was designed and synthesized for the purpose of detecting protamine and trypsin activity. The anionic probe self-assembled with protamine, driven by electrostatic and hydrophobic interactions, exhibiting a sensing behavior towards protamine in a fluorescence ratiometric manner. The assay demonstrated high sensitivity, with a limit of detection (LOD) of 13.8 ng/mL, and exhibited selectivity in the HEPES buffer solution. Moreover, the P4CG-protamine complex enables the monitoring of trypsin activity with satisfactory sensitivity and selectivity. The presence of the trypsin inhibitor resulted in the inhibition of the hydrolysis of protamine, which in turn led to a diminished fluorescence recovery. Consequently, this assay can be employed for the screening of trypsin inhibitors.
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Registered trials
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