ArticleMikrochimica acta2025
A SERS and colorimetric dual-mode biosensor based on stimulus-responsive DNA/MOF-bound bimetallic nanozyme for the ultrasensitive detection of chloramphenicol in food.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Clinical Laboratory Innovations: Nanoscale Detection of Chloramphenicol Using Nanomaterial Biosensors.Analytical science advances · 2026Review
- Bioengineering DNA-based hydrogels for regenerative medicine: A review of programmable design, chemical synthesis and therapeutic potential.Materials today. Bio · 2026Review
- Advances in Multifunctional Nanoagents and SERS-Based Multimodal Sensing for Biotoxin in Foods.Foods (Basel, Switzerland) · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
A dual-mode detection platform utilizing colorimetric and Raman was developed based on the exponential amplification reaction (EXPAR) strategy and a "core-satellite" structure constructed by bimetallic nanozymes to detect chloramphenicol (CAP). Initially, DNA-gated metal-organic frameworks (MOFs) incorporating cascaded amplification were used to be nanocarriers for the colorimetric and Raman reporter molecules (3,3',5,5'-tetramethylbiphenyl; TMB). Subsequently, assembled DNA served as gatekeepers to create a stimulus-responsive DNA-gated MOF (TMB@DNA/MOF). Upon the introduction of the target, the efficient and isothermal EXPAR was initiated, producing numerous amplicons that facilitated the unlocking of pores and subsequent release of TMB. This process amplified the release signal, enhancing the selectivity and sensitivity of the biosensor. Moreover, through base complementary pairing, TMB@DNA/MOF and magnetic bimetallic nanozymes Fe
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Registered trials
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