Evidence map›Paper›PMID 39786651›Full record

ArticleCancer causes & control : CCC2025

Temporal trends and patterns for early- and late-onset adult liver cancer incidence vary by race/ethnicity, subsite, and histologic type in the United States from 2000 to 2019.

Mei-Chin Hsieh, Kendra L Ratnapradipa, Laura Rozek, Shengdi Wen, Yu-Wen Chiu, Edward S Peters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mei-Chin HsiehEpidemiology and Population Health Program, School of Public Health, Louisiana State University Health Sciences Center, 2020 Gravier St., 3Rd Floor, , New Orleans, LA, 70112, USA. mhsieh@lsuhsc.edu.ORCID http://orcid.org/0000-0001-7842-1225
Kendra L RatnapradipaEpidemiology Department, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Laura RozekOncology Academic Department, Georgetown University Medical Center, Washington, DC, 20057, USA.
Shengdi WenEpidemiology and Population Health Program, School of Public Health, Louisiana State University Health Sciences Center, 2020 Gravier St., 3Rd Floor, , New Orleans, LA, 70112, USA.
Yu-Wen ChiuEpidemiology and Population Health Program, School of Public Health, Louisiana State University Health Sciences Center, 2020 Gravier St., 3Rd Floor, , New Orleans, LA, 70112, USA.
Edward S PetersEpidemiology Department, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

Centers for Disease Control and Prevention under cooperative agreement of the National Program of Cancer Registries NU58DP007112NCI NIH HHS HHSN2612018000071
6 · The paper itself

Abstract

purposeTo examine incidence trends and patterns for early- and late-onset liver cancer.

methodsLiver and intrahepatic bile duct (IBD) cancers diagnosed between 2000 and 2019 were acquired from 22 SEER registries. Variables included early-onset (20-49) vs. late-onset (50+), anatomic subsite, histologic type (hepatocellular carcinoma [HCC] and IBD cholangiocarcinoma [ICC]), sex, and race/ethnicity. Age-standardized incidence rates were calculated using SEER*Stat. Jointpoint regression analysis was employed to estimate the annual percent change (APC) and the average APC (AAPC) with pairwise comparisons for trend by sex and by race/ethnicity stratified by age and subsite.

resultsLiver cancer incidence decreased among early-onset (AAPC [95% CI] - 2.39 [- 2.74, - 2.07]) but increased among late-onset patients (2.85 [2.71, 3.01]), primarily driven by HCC (3.60 [3.50, 3.71]). IBD incidence increased for both ages with ICC incidence annually increasing 7.92% (6.84, 9.26) for early-onset and 6.32% (5.46, 8.86) for late-onset patients. Early-onset liver cancer displayed comparable trends across racial/ethnic groups; however, late-onset liver cancer showed more variation, particularly among American Indian/Alaska Native/Asian Pacific Islander (AI/AN/API) populations, which experienced a significant decrease in incidence, thereby narrowing the gap with other racial/ethnic groups. For IBD, an identical pattern of early-onset IBD among non-Hispanic Blacks (NHBs) compared to Hispanics was showed with coincidence test p = 0.1522, and a parallel pattern was observed among late-onset patients for both sexes (p = 0.5087).

conclusionLate-onset HCC continues to rise, except for NHB and AI/AN/API, where incidence rates have started to decrease over the past 4-5 years. Early and late-onset ICC incidence continues to increase across all racial/ethnic groups.

Indexed as

Bile Duct NeoplasmsCarcinoma, HepatocellularCholangiocarcinomaEthnicityLiver NeoplasmsAdultAgedAge of OnsetAmerican Indian or Alaska NativeFemaleHumansIncidenceMaleMiddle AgedRacial GroupsSEER ProgramCholangiocarcinoma (ICC)Hepatocellular carcinoma (HCC)Intrahepatic bile duct cancerLiver cancerTrend analysis

Identifiers

PMID39786651
PMCPMC11982089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.