Evidence map›Paper›PMID 39786641›Full record

ArticleMycopathologia2025

Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy.

Ramzi Kechaou, Denis Magne, Yaye Senghor, Cécile Brin, Karine Louvion, Laurene Parrot, Marjolaine Morgand, Céline Nourrisson, Philippe Poirier, Jeanne Bigot and 2 more

Abstract readCase Reports
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In one paragraph

Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramzi KechaouAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 75012, Paris, France.
Denis MagneAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 75012, Paris, France.
Yaye SenghorAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 75012, Paris, France.
Cécile BrinCentre Hospitalier Métropole Savoie, Service de Dermatologie, 73000, Chambéry, France.
Karine LouvionSorbonne Université, Hepatology Department, Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, French Network for Rare Liver Diseases in Adults and Children (FILFOIE), Saint-Antoine Hospital, (APHP), INSERM, UMR-S 938, CDR Saint-Antoine, Sorbonne Université, Paris, France.
Laurene ParrotUniversité Paris-Saclay, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
Marjolaine MorgandSorbonne Université, AP-HP, Hôpital Saint-Antoine, Service de Médecine Interne, 75012, Paris, France.
Céline NourrissonNational Reference Center for Cryptosporidiosis, Microsporidia and Other Digestive Protozoa (CNR CMAP), Department of Parasitology, Clermont-Ferrand University Hospital, 3iHP, Clermont-Ferrand, INSERM, University Clermont Auvergne, Clermont-Ferrand, France.
Philippe PoirierNational Reference Center for Cryptosporidiosis, Microsporidia and Other Digestive Protozoa (CNR CMAP), Department of Parasitology, Clermont-Ferrand University Hospital, 3iHP, Clermont-Ferrand, INSERM, University Clermont Auvergne, Clermont-Ferrand, France.
Jeanne BigotSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, , Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 75012, Paris, France.
Christophe HennequinSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, , Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 75012, Paris, France.
Alicia Moreno-SabaterSorbonne Université, Inserm U1135, Centre d'Immunologie et de Maladies Infectieuses (Cimi-Paris), AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, 184 rue Faubourg Saint Antoine, 175012, Paris, France. alicia.moreno@aphp.fr.ORCID http://orcid.org/0000-0002-7571-9533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present Enterocytozoon bieneusi infection in four patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Two patients suffered from inflammatory bowel disease and received anti-TNF therapies, whereas two other patients suffered from systemic lupus erythematosus with renal involvement and received anti-CD20 or anti-BLyS protein therapies. Three out of four patients consulted for diarrhea with abdominal pain without intestinal inflammation or bleeding at the time of sampling. The fourth patient did not declare intestinal troubles. Microsporidia genotype detected in this study were S9, C, Wildboard3 with one patient harboring 2 genotypes S6 and EBCMAP-038. Management of microsporidia infection included albendazole and reduction of immunosuppression treatment, but no specific treatment was implemented in two other patients. In conclusion, microsporidia infection occurs in patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Diagnosis should be carefully assessed in this population and a thorough benefit-risk analysis is essential prior to initiating therapeutic interventions.

Indexed as

Antibodies, MonoclonalAutoimmune DiseasesMicrosporidiosisAlbendazoleEnterocytozoonGenotypeHumansImmunotherapyAlbendazoleAntibodies, MonoclonalAlbendazoleAutoimmune diseasesClinical managementEnterocytozoon bieneusiMicrosporidiosisMonoclonal antibody

Identifiers

PMID39786641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.