Evidence map›Paper›PMID 39786590›Full record

ArticleArchives of toxicology2025

E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model.

Ibrahim M Sayed, Anirban Chakraborty, Kaili Inouye, Leanne Dugan, Stefania Tocci, Ira Advani, Kenneth Park, Samvel Gaboyan, Nikita Kasaraneni, Benjamin Ma and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ibrahim M SayedDepartment of Pathology, University of California, San Diego, CA, 92093, USA. Ibrahim_ibrahim@uml.edu.ORCID 0000-0001-8207-6401
Anirban ChakrabortyDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Kaili InouyeDepartment of Pathology, University of California, San Diego, CA, 92093, USA.
Leanne DuganDepartment of Pathology, University of California, San Diego, CA, 92093, USA.
Stefania TocciDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Ira AdvaniDepartment of Medicine, University of California, San Diego, CA, 92093, USA.
Kenneth ParkDepartment of Medicine, University of California, San Diego, CA, 92093, USA.
Samvel GaboyanDepartment of Medicine, University of California, San Diego, CA, 92093, USA.
Nikita KasaraneniDepartment of Medicine, University of California, San Diego, CA, 92093, USA.
Benjamin MaDepartment of Medicine, University of California, San Diego, CA, 92093, USA.
Tapas K HazraDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Soumita DasDepartment of Pathology, University of California, San Diego, CA, 92093, USA. soumita_das@uml.edu.
Laura E Crotty AlexanderDepartment of Medicine, University of California, San Diego, CA, 92093, USA. lca@ucsd.edu.

Funding

Preferential single-strand break repair in the active genes of mammalian cellsR01NS073976 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K · 2012 to 2021
$3.3M
Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory PathwaysR01HL137052 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CROTTY ALEXANDER, LAURA ELISE · 2017 to 2021
$2.3M
Innate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2M
Prospective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5M
Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When VapedK24HL155884 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander · 2022 to 2026
$609k
DNA double strand break repair deficiency and neurodegenerationR56NS073976 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K · 2024 to 2024
$536k
The host-microbe-metformin interplay in the aged gutR56AG069689 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2020 to 2020
$394k
BLRD VA I01 BX004767BLRD VA I01 BX006447NCIRD CDC HHS U01 IP000965NHLBI NIH HHS K24 HL155884NHLBI NIH HHS R01 HL137052NHLBI NIH HHS R01 HL147326NIA NIH HHS R56 AG069689NIDDK NIH HHS R01 DK107585NIH HHS 2R01 NS073976NIH HHS AG069689NIH HHS DK107585NIH HHS K24HL155884NIH HHS R01HL137052NIH HHS R01HL147326NIH HHS R56NS073976.NINDS NIH HHS R01 NS073976NINDS NIH HHS R56 NS073976Tobacco-Related Disease Research Program T30IP0965Tobacco-Related Disease Research Program T32SR5359
6 · The paper itself

Abstract

E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.cig vaping promotes inflammation and gut leakiness. Further, E.cig vaping increases tumorigenesis in oral and lung epithelial cells by inducing mutations and suppressing host DNA repair enzymes. It is well known that cigarette (cig) smoking increases the risk of colorectal cancer (CRC). To date, it is unknown whether E.cig vaping impacts CRC development. A mouse model of human familial adenomatous polyposis (CPC-APC) was utilized wherein a mutation in the adenomatous polyposis coli (APC) gene, CDX2-Cre-APC

Indexed as

AdenomaColorectal NeoplasmsElectronic Nicotine Delivery SystemsVapingAdenomatous Polyposis ColiAnimalsDisease Models, AnimalDNA DamageDNA GlycosylasesFemaleGenes, APCHumansMaleMiceMice, Inbred C57BLDNA GlycosylasesCigarette smokingColorectal cancerCPC-APC miceDNA damageDNA glycosylaseDual useE.cigInflammationStemness markers

Identifiers

PMID39786590
PMCPMC12860471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.