Evidence map›Paper›PMID 39786561›Full record

ArticleEuropean journal of applied physiology2025

The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity.

M D'Alleva, J M Sanz, N Giovanelli, F Graniero, L Mari, R Spaggiari, D Sergi, S Ghisellini, A Passaro, S Lazzer

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In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M D'Alleva *Department of Medicine, University of Udine, P. le Kolbe 4 - 33100, Udine, Italy. mattia.dalleva@uniud.it.ORCID http://orcid.org/0000-0001-9179-1618
J M Sanz *Department of Chemical and Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
N GiovanelliDepartment of Medicine, University of Udine, P. le Kolbe 4 - 33100, Udine, Italy.
F GranieroPhysical Exercise Prescription Center, Azienda Sanitaria Universitaria Friuli Centrale, Gemona del Friuli, Udine, Italy.
L MariDepartment of Medicine, University of Udine, P. le Kolbe 4 - 33100, Udine, Italy.
R SpaggiariDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
D SergiDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
S GhiselliniBiochemical Analysis Laboratory - Clinics and Microbiology, University Hospital of Ferrara, Ferrara, Italy.
A PassaroDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
S LazzerDepartment of Medicine, University of Udine, P. le Kolbe 4 - 33100, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.

methodsSeventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m

resultsThe concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P < 0.05), whereas eGRF decreased at T1 (P < 0.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (P < 0.05). A positive association was observed between ΔCK-MB (%) and the time spent in Zone 3 during the race (R = 0.686, P = 0.014). The Δmyoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (R = 0.574-0.862, P < 0.05). The ∆CREA values were moderately correlated with the race mean HR

conclusionChanges in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.

Indexed as

ExerciseKidneyMuscle, SkeletalObesityAdultBiomarkersGlomerular Filtration RateHumansMaleMiddle AgedMyoglobinRunningTroponin IBiomarkersMyoglobinTroponin ICardiac damageCardiorespiratory fitnessHalf-marathonMarathonMuscular damageObesityRenal injury

Identifiers

PMID39786561
PMCPMC12055649

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.